| Genetic analysis of abdominal fat distribution in SM/J and A/J mice. | |
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MedLine Citation:
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PMID: 20802160 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Each abdominal fat depot, such as mesenteric or epididymal, differently contributes to the development of insulin resistance. The aim of this study was to identify the genetic regions that contribute to fat accumulation in epididymal/mesenteric fat and to examine whether or not the genetic regions that affect glucose metabolism and body fat distribution are coincident. We previously mapped a major quantitative trait locus (QTL) (T2dm2sa) for impaired glucose tolerance on chromosome 2 and revealed that SM.A-T2dm2sa congenic mice showed not only glucose tolerance but also fat accumulation. In the present study, to identify the loci/genes that control the accumulation of abdominal fat, we performed QTL analyses of epididymal/mesenteric fat weight by using (A/J x SM.A-T2dm2sa)F2 mice in which the effect of T2dm2sa was excluded. As a result, two highly significant QTLs for mesenteric fat, as well as three significant QTLs for epididymal/mesenteric fat, were mapped on the different chromosomal regions. This suggests that the fat accumulations in individual fat depots are controlled by distinct genomic regions. Our comparison of these QTLs for abdominal fat distribution with those for glucose metabolism revealed that the major genetic factors affecting body fat distribution do not coincide with genetic factors affecting glucose metabolism in (A/J x SM.A-T2dm2sa)F2. |
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Authors:
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Misato Kobayashi; Tamio Ohno; Natsuko Hada; Masato Fujiyoshi; Masako Kuga; Masahiko Nishimura; Atsushi Murai; Fumihiko Horio |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-27 |
Journal Detail:
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Title: Journal of lipid research Volume: 51 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-10 Completed Date: 2011-02-22 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: United States |
Other Details:
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Languages: eng Pagination: 3463-9 Citation Subset: IM |
Affiliation:
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Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Fat
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drug effects*,
metabolism Animals Blood Glucose / genetics*, metabolism Body Weight / drug effects Chromosomes, Mammalian Diabetes Mellitus / genetics*, metabolism Dietary Fats / administration & dosage, pharmacology* Disease Models, Animal Epididymis / drug effects, metabolism Female Genome Glucose Tolerance Test Male Mice Mice, Congenic Mice, Inbred Strains Obesity, Abdominal / genetics*, metabolism Quantitative Trait Loci Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Dietary Fats |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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