Document Detail

Genetic analysis of Saccharomyces cerevisiae SY 15 relaxed mutant.
MedLine Citation:
PMID:  6387389     Owner:  NLM     Status:  MEDLINE    
Evidence is presented showing that the relaxed phenotype of the SY15 mutant is determined by one nuclear recessive mutation. The most characteristic patterns of the relaxed phenotype in yeast - rRNA accumulation and rRNA processing in the absence of protein synthesis were found to segregate together in first and second generation crosses. Therefore, the interruption of rRNA processing that occurs after starvation for a required amino acid is a pleiotropic manifestation of the stringent control itself. It is suggested that the locus for the stringent response in Saccharomyces cerevisiae (designated STR) coordinates the synthesis of rRNA on transcriptional and post-transcriptional levels.
L I Stateva; P V Venkov
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular & general genetics : MGG     Volume:  195     ISSN:  0026-8925     ISO Abbreviation:  Mol. Gen. Genet.     Publication Date:  1984  
Date Detail:
Created Date:  1984-11-26     Completed Date:  1984-11-26     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0125036     Medline TA:  Mol Gen Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  234-7     Citation Subset:  IM    
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MeSH Terms
Genes, Fungal*
Genes, Recessive*
RNA, Ribosomal / genetics,  isolation & purification
Saccharomyces cerevisiae / genetics*
Transcription, Genetic
Reg. No./Substance:
0/RNA, Ribosomal

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