| Genetic amniocentesis in women 20-34 years old: associated risks. | |
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MedLine Citation:
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PMID: 10719331 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this retrospective controlled study is to evaluate the impact of predisposing factors on amniocentesis-related fetal loss. It comprises 3910 consecutive cases of women, aged 20-34 years, who had genetic amniocentesis during the years 1992-97 (study group). The control group comprised 5324 women under 35, at low risk for Down syndrome, during the same period. The fetal losses in both groups were analysed, in respect of: (a) maternal historical conditions; and/or (b) bleeding during current pregnancy. The leading indication for amniocentesis in women 20-34 years was maternal anxiety, mainly for marginal age (33-34 years), which accounted for a remarkable 34.4% of the study group. Total fetal loss rate up to the 28th week was 2.1% in the study group versus 1. 5% in controls. A history of previous spontaneous or induced abortions, as well as bleeding during the current pregnancy, was associated with a substantial rise of fetal loss in both groups. In cases with no predisposing factors, the added fetal loss rate was 0.03%. Previous abortions and bleeding during the current pregnancy are associated with the most fetal losses after amniocentesis. In the absence of these, the added fetal loss rate (0.03%) is non-significant. |
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Authors:
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A Antsaklis; N Papantoniou; A Xygakis; S Mesogitis; E Tzortzis; S Michalas |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 20 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2000-05-11 Completed Date: 2000-05-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 247-50 Citation Subset: IM |
Copyright Information:
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Copyright 2000 John Wiley & Sons, Ltd. |
Affiliation:
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1st Department of Obstetrics and Gynecology, Maternal Fetal Medicine Unit, University of Athens, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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etiology Adult Amniocentesis / adverse effects* Anxiety Chromosome Aberrations* Female Fetal Death / etiology Gestational Age Humans Placenta / injuries Pregnancy Pregnancy Outcome Retrospective Studies Uterine Hemorrhage |
| Comments/Corrections | |
Comment In:
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Prenat Diagn. 2000 Dec;20(12):1018
[PMID:
11113919
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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