Document Detail


Genetic admixture, social-behavioural factors and body composition are associated with blood pressure differently by racial-ethnic group among children.
MedLine Citation:
PMID:  21248781     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiovascular disease has a progressively earlier age of onset, and disproportionately affects African Americans (AAs) in the United States. It has been difficult to establish the extent to which group differences are due to physiological, genetic, social or behavioural factors. In this study, we examined the association between blood pressure and these factors among a sample of 294 children, identified as AA, European American or Hispanic American. We use body composition, behavioural (diet and physical activity) and survey-based measures (socio-economic status and perceived racial discrimination), as well as genetic admixture based on 142 ancestry informative markers (AIMs) to examine associations with systolic and diastolic blood pressure. We find that associations differ by ethnic/racial group. Notably, among AAs, physical activity and perceived racial discrimination, but not African genetic admixture, are associated with blood pressure, while the association between blood pressure and body fat is nearly absent. We find an association between blood pressure and an AIM near a marker identified by a recent genome-wide association study. Our findings shed light on the differences in risk factors for elevated blood pressure among ethnic/racial groups, and the importance of including social and behavioural measures to grasp the full genetic/environmental aetiology of disparities in blood pressure.
Authors:
Y C Klimentidis; A Dulin-Keita; K Casazza; A L Willig; D B Allison; J R Fernandez
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-01-20
Journal Detail:
Title:  Journal of human hypertension     Volume:  26     ISSN:  1476-5527     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-12     Completed Date:  2012-05-08     Revised Date:  2014-05-02    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  98-107     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
African Americans* / genetics,  psychology
Alabama / epidemiology
Blood Pressure* / genetics
Body Composition / genetics*
Child
Cross-Sectional Studies
European Continental Ancestry Group* / genetics,  psychology
Female
Genetic Markers
Genetic Predisposition to Disease
Health Behavior / ethnology*
Health Status Disparities*
Hispanic Americans* / genetics,  psychology
Humans
Hypertension / ethnology*,  genetics,  physiopathology,  psychology
Linear Models
Male
Markov Chains
Monte Carlo Method
Risk Assessment
Risk Factors
Socioeconomic Factors*
Grant Support
ID/Acronym/Agency:
CA47888/CA/NCI NIH HHS; P30 DK056336/DK/NIDDK NIH HHS; P30 DK056336-01/DK/NIDDK NIH HHS; P30-DK56336/DK/NIDDK NIH HHS; P60 DK079626-01/DK/NIDDK NIH HHS; P60-DK079626/DK/NIDDK NIH HHS; R01 DK067426-01/DK/NIDDK NIH HHS; R01-DK067426/DK/NIDDK NIH HHS; T32 HL007457-30/HL/NHLBI NIH HHS; T32 HL105346/HL/NHLBI NIH HHS; T32-HL007457/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers
Comments/Corrections

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