| Genetic activities in micronuclei: is the DNA entrapped in micronuclei lost for the cell? | |
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MedLine Citation:
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PMID: 20307686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Micronuclei are good markers of genotoxic exposure in humans and their scoring has been extensively used to identify potential genotoxic agents. Micronuclei are also indicators of chromosomal instability, since the frequency of micronuclei is higher in tumour cells and cells with a defective DNA damage repair system or disrupted cell cycle checkpoint machinery. Despite the widespread use of this biomarker, information on the basic biology of micronuclei and the impact of micronuclei on the cell is relatively controversial. In some cell systems, micronuclei are considered to be genetic material that is lost for the cell; whereas other studies suggest that micronuclear DNA is actively transcribed and its genes are fully expressed. Recently, evidence has accumulated suggesting that damaged DNA entrapped in micronuclei induces a defective cell cycle checkpoint arrest and DNA repair response, and that micronuclear content can be degraded without inducing an immediate cell cycle arrest or causing the cell to enter apoptosis. Overall, these findings emphasise the important consequences of micronucleus formation in terms of chromosomal instability in general and gene loss in particular. |
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Authors:
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Mariona Terradas; Marta Martín; Laura Tusell; Anna Genescà |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-03-20 |
Journal Detail:
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Title: Mutation research Volume: 705 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 2010 Jul-Sep |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-08-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 60-7 Citation Subset: IM |
Copyright Information:
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2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis Cell Cycle / genetics Chromosomal Instability DNA Damage* DNA Repair Humans Micronuclei, Chromosome-Defective* |
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