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Genetic Variation in Putative Salt Taste Receptors and Salt Taste Perception in Humans.
MedLine Citation:
PMID:  23118204     Owner:  NLM     Status:  Publisher    
The objective of this study was to determine whether single nucleotide polymorphisms (SNPs) in the SCNN1A (3), SCNN1B (12), SCNN1G (6), and TRPV1 (10) genes affect salt taste perception. Participants were men (n = 28) and women (n = 67) from the Toronto Nutrigenomics and Health study aged 21-31 years. Taste thresholds were determined using a 3-alternative forced-choice staircase model with solutions ranging from 9×10(-6) to 0.5mol/L. Suprathreshold taste sensitivity to 0.01-1.0mol/L salt solutions was assessed using general labeled magnitude scales. None of the SNPs in the SCNN1A and SCNN1G genes were significantly associated with either outcome. In the SCNN1B gene, 2 SNPs in intronic regions of the gene modified suprathreshold taste sensitivity (mean iAUC ± SE). Those homozygous for the A allele of the rs239345 (A>T) polymorphism and the T allele of the rs3785368 (C>T) polymorphism perceived salt solutions less intensely than carriers of the T or C alleles, respectively (rs239345: 70.82±12.16 vs. 96.95±3.75, P = 0.02; rs3785368: 57.43±19.85 vs. 95.57±3.66, P = 0.03) In the TRPV1 gene, the rs8065080 (C>T, Val585Ile) polymorphism modified suprathreshold taste sensitivity where carriers of the T allele were significantly more sensitive to salt solutions than the CC genotype (98.3±3.8 vs. 74.1±8.3, P = 0.008). Our findings show that variation in the TRPV1 and the SCNN1B genes may modify salt taste perception in humans.
Andre G Dias; Dérick Rousseau; Lisa Duizer; Moira Cockburn; Winnie Chiu; Daiva Nielsen; Ahmed El-Sohemy
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-1
Journal Detail:
Title:  Chemical senses     Volume:  -     ISSN:  1464-3553     ISO Abbreviation:  Chem. Senses     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8217190     Medline TA:  Chem Senses     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Nutritional Sciences, University of Toronto, Canada.
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