| Genetic variation in the indoleamine 2,3-dioxygenase gene in pre-eclampsia. | |
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MedLine Citation:
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PMID: 20192952 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PROBLEM: To investigate the contribution of genomic variations in the indoleamine 2,3-dioxygenase (IDO) gene to the onset of pre-eclampsia. METHOD OF STUDY: We examined sequence variations in the IDO1 gene using placental genomic DNA from 35 pre-eclamptic patients and 32 normotensive pregnant women. RESULTS: A case-control study revealed that none of the common variants influences the risk of disease. Sequencing of each IDO1 exon in diseased subjects revealed rare variants. This variation, c.-147_150delGAAA, was located within the 5'-untranslated region of the IDO1 gene, and its homozygote was identified only in pre-eclamptic subjects. However, despite the low levels of IDO expression and enzyme activity in the c.-147_150delGAAA homozygote, reporter assays indicated that this variation does not affect gene expression. CONCLUSION: Our findings indicate that genetic alteration of fetal IDO gene does not appear to be a primary cause of pre-eclampsia. |
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Authors:
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Haruki Nishizawa; Takema Kato; Sayuri Ota; Sachie Nishiyama; Kanako Pryor-Koishi; Machiko Suzuki; Makiko Tsutsumi; Hidehito Inagaki; Hiroki Kurahashi; Yasuhiro Udagawa |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-28 |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 64 ISSN: 1600-0897 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-01 Completed Date: 2010-08-27 Revised Date: 2010-11-09 |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 68-76 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Case-Control Studies Female Genetic Variation* Humans Indoleamine-Pyrrole 2,3,-Dioxygenase / genetics* Mice Placenta / metabolism Pre-Eclampsia / genetics* Pregnancy |
| Chemical | |
Reg. No./Substance:
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EC 1.13.11.42/Indoleamine-Pyrrole 2,3,-Dioxygenase |
| Comments/Corrections | |
Comment In:
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Am J Reprod Immunol. 2010 Nov;64(5):316; author reply 317
[PMID:
20584013
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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