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Genetic Variation in GSTM1 Is Associated With Susceptibility to Noise-Induced Hearing Loss in a Chinese Population.
MedLine Citation:
PMID:  22885711     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES:: To investigate whether glutathione S-transferases (GST) genetic polymorphisms (GSTT1 rs1049055, GSTM1 rs10712361, and GSTP1 rs1695) are associated with susceptibility to noise-induced hearing loss (NIHL). METHODS:: These polymorphisms were analyzed in 444 NIHL and 445 normal hearing workers. In addition, total plasma GST activity was measured in all subjects. RESULTS:: Individuals with the GSTM1 null genotype had a statistically significantly increased risk of NIHL (odds ratio [OR] = 1.64, 95% confidence interval [CI] = 1.26 to 2.13) compared with those carrying a wild-type GSTM1 genotype. This effect was more pronounced among the workers exposed to 86 to 91 dB(A) (OR = 3.35, 95% CI = 1.54 to 7.31). Glutathione S-transferase activity of the NIHL workers was also lower than that of normal hearing workers (14.5 ± 5.1 U/ml vs 15.9 ± 6.3 U/ml, P = 0.010). CONCLUSION:: Our results suggest that GSTM1 polymorphism is associated with susceptibility to NIHL.
Authors:
Huanxi Shen; Xinying Huo; Kai Liu; Xiuting Li; Wei Gong; Hengdong Zhang; Yanqiong Xu; Meilin Wang; Xin Li; Jing Zhang; Zhengdong Zhang; Baoli Zhu
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-9
Journal Detail:
Title:  Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine     Volume:  -     ISSN:  1536-5948     ISO Abbreviation:  J. Occup. Environ. Med.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504688     Medline TA:  J Occup Environ Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the Department of Occupational Medicine and Environmental Health (Drs Shen, Huo, Xiuting Li, Wang, Xin Li, Zhengdong Zhang, and Zhu), the Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China; Institute of Occupational Disease Prevention (Drs Shen, Xiuting Li, Gong, Hengdon Zhang, Xu, and Zhu), Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, China; Department of Molecular & Genetic Toxicology (Drs Huo, Wang, Xin Li, and Zhengdong Zhang), Jiangsu Key Laboratory of Cancer Biomarkers, Prevention & Treatment, Cancer Center, Nanjing Medical University, Nanjing, China; Department of Disease Prevention, (Dr Kai Liu) The Third Affiliated Hospital of Nanjing Medical University, Yizheng, China; and Department of Safety (Dr Jing Zhang), Chenguang Machinery Manufacturing Group Corporation, Nanjing, China.
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