Document Detail


Genetic variants of XRCC1, APE1, and ADPRT genes and risk of bladder cancer.
MedLine Citation:
PMID:  20218899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
DNA damaged by exposure to exogenous and endogenous carcinogens could be removed effectively by the base excision repair pathway, in which the XRCC1, APE1, and ADPRT genes play a key role. Genetic variations in these important genes may alter repair function and contribute to cancer risk. We hypothesized that XRCC1, APE1, and ADPRT polymorphisms are associated with risk of bladder cancer. In a hospital-based case-control study of 234 patients with bladder cancer and 253 cancer-free controls, we genotyped the XRCC1-77T>C, Arg194Trp, Arg280His, Arg399Gln, APE1-656T>G, Asp148Glu, ADPRT-442G>A, and Val762Ala polymorphisms using polymerase chain reaction-restriction fragment length polymorphism method. We found an increased risk of bladder cancer associated with the XRCC1 194Trp/Trp and 280Arg/His genotypes (adjusted odds ratio = 3.90, 95% confidence interval = 1.69-8.98 for 194Trp/Trp and 2.53, 1.67-3.83 for 280Arg/His) compared with the 194Arg/Arg and 280Arg/Arg genotypes, respectively. In contrast, the APE1-656GG genotype was associated with a decreased risk of bladder cancer (0.57, 0.33-0.98) compared with the TT genotype. When we evaluated these eight polymorphisms together, we found that the combined genotypes with 9-13 variant (risk) alleles were associated with an increased risk of bladder cancer (2.25, 1.48-3.40) compared with those with 3-8 variants. These findings suggest that the XRCC1 and APE1 polymorphisms may contribute to susceptibility to bladder cancer. Larger studies are warranted to verify these findings.
Authors:
Meilin Wang; Chao Qin; Jian Zhu; Lin Yuan; Guangbo Fu; Zhengdong Zhang; Changjun Yin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  DNA and cell biology     Volume:  29     ISSN:  1557-7430     ISO Abbreviation:  DNA Cell Biol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-18     Completed Date:  2010-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9004522     Medline TA:  DNA Cell Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  303-11     Citation Subset:  IM    
Affiliation:
Department of Molecular and Genetic Toxicology, Cancer Center of Nanjing Medical University, Nanjing, China.
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MeSH Terms
Descriptor/Qualifier:
ADP Ribose Transferases / genetics*
Adult
Aged
Case-Control Studies
DNA-(Apurinic or Apyrimidinic Site) Lyase / genetics*
DNA-Binding Proteins / genetics*
Female
Gene Frequency
Genetic Predisposition to Disease*
Genetic Variation*
Genotype
Hospitals
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Urinary Bladder Neoplasms / genetics*
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/X-ray repair cross complementing protein 1; EC 2.4.2.-/ADP Ribose Transferases; EC 4.2.99.18/APEX1 protein, human; EC 4.2.99.18/DNA-(Apurinic or Apyrimidinic Site) Lyase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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