Document Detail

Genetic variants of XRCC1, APE1, and ADPRT genes and risk of bladder cancer.
MedLine Citation:
PMID:  20218899     Owner:  NLM     Status:  MEDLINE    
DNA damaged by exposure to exogenous and endogenous carcinogens could be removed effectively by the base excision repair pathway, in which the XRCC1, APE1, and ADPRT genes play a key role. Genetic variations in these important genes may alter repair function and contribute to cancer risk. We hypothesized that XRCC1, APE1, and ADPRT polymorphisms are associated with risk of bladder cancer. In a hospital-based case-control study of 234 patients with bladder cancer and 253 cancer-free controls, we genotyped the XRCC1-77T>C, Arg194Trp, Arg280His, Arg399Gln, APE1-656T>G, Asp148Glu, ADPRT-442G>A, and Val762Ala polymorphisms using polymerase chain reaction-restriction fragment length polymorphism method. We found an increased risk of bladder cancer associated with the XRCC1 194Trp/Trp and 280Arg/His genotypes (adjusted odds ratio = 3.90, 95% confidence interval = 1.69-8.98 for 194Trp/Trp and 2.53, 1.67-3.83 for 280Arg/His) compared with the 194Arg/Arg and 280Arg/Arg genotypes, respectively. In contrast, the APE1-656GG genotype was associated with a decreased risk of bladder cancer (0.57, 0.33-0.98) compared with the TT genotype. When we evaluated these eight polymorphisms together, we found that the combined genotypes with 9-13 variant (risk) alleles were associated with an increased risk of bladder cancer (2.25, 1.48-3.40) compared with those with 3-8 variants. These findings suggest that the XRCC1 and APE1 polymorphisms may contribute to susceptibility to bladder cancer. Larger studies are warranted to verify these findings.
Meilin Wang; Chao Qin; Jian Zhu; Lin Yuan; Guangbo Fu; Zhengdong Zhang; Changjun Yin
Related Documents :
20944139 - Significant association of methylenetetrahydrofolate reductase single nucleotide polymo...
15892999 - Polymorphisms in the promoter region of neutrophil elastase gene and lung cancer risk.
19357349 - Association of common genetic variants in smad7 and risk of colon cancer.
19125129 - Can ugt1a1 genotyping reduce morbidity and mortality in patients with metastatic colore...
11916629 - Aromatase and breast cancer: w39r, an inactive protein.
21120789 - [fertility and cancer--outlining of the issue].
9615709 - Deletion of chromosome 3p is an early event in malignant progression of cervical cancer.
14996859 - Quality of life at the end of primary treatment of breast cancer: first results from th...
8590139 - Clinical applications of epidermal growth factor.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  DNA and cell biology     Volume:  29     ISSN:  1557-7430     ISO Abbreviation:  DNA Cell Biol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-18     Completed Date:  2010-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9004522     Medline TA:  DNA Cell Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  303-11     Citation Subset:  IM    
Department of Molecular and Genetic Toxicology, Cancer Center of Nanjing Medical University, Nanjing, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
ADP Ribose Transferases / genetics*
Case-Control Studies
DNA-(Apurinic or Apyrimidinic Site) Lyase / genetics*
DNA-Binding Proteins / genetics*
Gene Frequency
Genetic Predisposition to Disease*
Genetic Variation*
Middle Aged
Polymorphism, Single Nucleotide
Urinary Bladder Neoplasms / genetics*
Reg. No./Substance:
0/DNA-Binding Proteins; 0/X-ray repair cross complementing protein 1; EC 2.4.2.-/ADP Ribose Transferases; EC protein, human; EC or Apyrimidinic Site) Lyase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A Functional Promoter Polymorphism in NFKB1 Increases Susceptibility to Endometriosis.
Next Document:  Assessment of Genetic Damage in Buccal Epithelium Cells of Painters: Micronucleus, Nuclear Changes, ...