Document Detail


Genetic variants and blood pressure in a population-based cohort: the Cardiovascular Risk in Young Finns study.
MedLine Citation:
PMID:  22025373     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinical relevance of a genetic predisposition to elevated blood pressure was quantified during the transition from childhood to adulthood in a population-based Finnish cohort (N=2357). Blood pressure was measured at baseline in 1980 (age 3-18 years) and in follow-ups in 1983, 1986, 2001, and 2007. Thirteen single nucleotide polymorphisms associated with blood pressure were genotyped, and 3 genetic risk scores associated with systolic and diastolic blood pressures and their combination were derived for all of the participants. Effects of the genetic risk score were 0.47 mm Hg for systolic and 0.53 mm Hg for diastolic blood pressures (both P<0.01). The combination genetic risk score was associated with diastolic blood pressure from age 9 years onward (β=0.68 mm Hg; P=0.015). Replications in 1194 participants of the Bogalusa Heart Study showed essentially similar results. The participants in the highest quintile of the combination genetic risk score had a 1.82-fold risk of hypertension in adulthood (P<0.0001) compared with the lowest quintile, independent of a family history of premature hypertension. These findings show that genetic variants are associated with preclinical blood pressure traits in childhood; individuals with several susceptibility alleles have, on average, a 0.5-mm Hg higher blood pressure, and this trajectory continues from childhood to adulthood.
Authors:
Mervi Oikonen; Emmi Tikkanen; Jonna Juhola; Tarja Tuovinen; Ilkka Seppälä; Markus Juonala; Leena Taittonen; Vera Mikkilä; Mika Kähönen; Samuli Ripatti; Jorma Viikari; Terho Lehtimäki; Aki S Havulinna; Frank Kee; Christopher Newton-Cheh; Leena Peltonen; Nicholas J Schork; Sarah S Murray; Gerald S Berenson; Wei Chen; Sathanur R Srinivasan; Veikko Salomaa; Olli T Raitakari
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-10-24
Journal Detail:
Title:  Hypertension     Volume:  58     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-18     Completed Date:  2012-01-03     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1079-85     Citation Subset:  IM    
Affiliation:
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, PO Box 52, FI-20521 Turku, Finland. mervi.oikonen@utu.fi
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Blood Pressure / genetics*
Body Mass Index
Child
Child, Preschool
Cohort Studies
Cross-Sectional Studies
Female
Finland / epidemiology
Follow-Up Studies
Genotype
Humans
Hypertension / epidemiology*,  genetics
Louisiana / epidemiology
Male
Middle Aged
Polymorphism, Single Nucleotide*
Risk
Smoking / epidemiology
Sodium, Dietary
Young Adult
Grant Support
ID/Acronym/Agency:
AG-16592/AG/NIA NIH HHS; HD-061437/HD/NICHD NIH HHS; HD-062783/HD/NICHD NIH HHS; R01 AG016592/AG/NIA NIH HHS; R01 AG016592-01A1/AG/NIA NIH HHS; //Wellcome Trust
Chemical
Reg. No./Substance:
0/Sodium, Dietary
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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