Document Detail


A genetic perspective on infant mortality.
MedLine Citation:
PMID:  20375941     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite significant advances in perinatal and neonatal medicine, infant mortality (IM) remains a significant public health problem. The causes of IM are complex, numerous, and a result of interacting genetic and environmental factors. This paper explores genetic contributions to IM using data from Virginia. Leading causes of IM in Virginia are disorders of prematurity/low birth weight, congenital anomalies, and sudden infant death syndrome (SIDS). Recognized single gene disorders as well as genetic polymorphisms are discussed in relation to their role in IM. While preconceptional prevention from a genetic standpoint may not currently be possible, this paper provides clinicians with information on identifying women at highest risk for IM and those in need of additional surveillance and intervention. Suggestions for simple health messages to provide to women of child-bearing age to decrease the risks for birth defects and obstetrical/perinatal complications resulting in IM are also discussed.
Authors:
Tahnee N Causey; Joann N Bodurtha; Nancy Ford
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Southern medical journal     Volume:  103     ISSN:  1541-8243     ISO Abbreviation:  South. Med. J.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-03     Completed Date:  2010-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  440-4; quiz 445-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298-0033, USA. tcausey@mcvh-vcu.edu
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MeSH Terms
Descriptor/Qualifier:
Congenital Abnormalities / genetics
Female
Humans
Infant
Infant Mortality*
Infant, Newborn
Pregnancy
Premature Birth / genetics
Sudden Infant Death / genetics
Grant Support
ID/Acronym/Agency:
5U50DD321127/DD/NCBDD CDC HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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