| Genetic markers and danger signals in stevens-johnson syndrome and toxic epidermal necrolysis. | |
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MedLine Citation:
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PMID: 20962567 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening adverse reactions, which could be induced by a variety of drugs. It was proposed that human leukocyte antigen (HLA)-restricted presentation of antigens (drugs or their metabolites) to T lymphocytes initiates the immune reactions of SJS/TEN. However, the genetic susceptibility and the exact pathogenesis were not clear until the recent studies. We first identified that HLA-B*1502 is strongly associated with carbamazepine (CBZ)-induced SJS/TEN and HLA-B*5801 with allopurinol-SJS/TEN in Han Chinese. The same associations had been validated across different human populations. For the downstream danger signals, Fas-Fas ligand (FasL) and perforin/granzyme B had been advocated as cytotoxic mediators for keratinocyte death in SJS/TEN. However, expression levels of these cytotoxic proteins from the skin lesions were too low to explain the distinct and extensive epidermal necrosis. Our recent study identified that the granulysin, a cytotoxic protein released from cytotoxic T cells or natural killer (NK) cells, is a key mediator for disseminated keratinocyte death in SJS/TEN. This article aims to provide an overview of both of the genomic and immunologic perspectives of SJS/TEN. These studies give us a better understanding of the immune mechanisms, biomarkers for disease prevention and early diagnosis, as well as providing the therapeutic targets for the treatments of SJS/TEN. |
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Authors:
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Wen-Hung Chung; Shuen-Iu Hung |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-25 |
Journal Detail:
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Title: Allergology international : official journal of the Japanese Society of Allergology Volume: 59 ISSN: 1440-1592 ISO Abbreviation: Allergol Int Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9616296 Medline TA: Allergol Int Country: Japan |
Other Details:
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Languages: eng Pagination: 325-32 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan. chung1@cgmh.org.tw |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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