Document Detail

Genetic Loci for Coronary Calcification and Serum Lipids Relate to Aortic and Carotid Calcification.
MedLine Citation:
PMID:  23247144     Owner:  NLM     Status:  Publisher    
BACKGROUND: -Atherosclerosis in different vessel beds shares lifestyle and environmental risk factors. We investigated whether this also holds for genetic risk factors. Hence, we used genetic loci for coronary artery calcification (CAC) and serum lipid levels -one of the strongest risk factors for atherosclerosis- to assess their relationship with atherosclerosis in different vessel beds. METHODS AND RESULTS: -In 1,987 persons from the population-based Rotterdam Study we used three SNPs (single nucleotide polymorphisms) for CAC and 132 SNPs for total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides. To quantify atherosclerotic calcification, as marker of atherosclerosis, all participants underwent non-enhanced CT of the aortic arch and carotid arteries. We investigated associations between genetic risk scores of the joint effect of the SNPs and calcification. The joint effect of CAC-SNPs was associated with larger calcification volumes in all vessel beds [difference in calcification volume per SD increase in genetic risk score 0.15(95%CI:0.11;0.20) in aorta, 0.14(95%CI:0.10;0.18) in extracranial carotids, 0.11(95%CI:0.07;0.16) in intracranial carotids]. The joint effect of total cholesterol-SNPs, LDL-SNPs and of all lipid SNPs together was associated with larger calcification volumes in both the aortic arch and the carotid arteries, but attenuated after adjusting for the lipid fraction and lipid lowering medication. CONCLUSIONS: -The genetic basis for aortic arch and carotid artery calcification overlaps with the most important loci of coronary artery calcification. Furthermore, serum lipids share a genetic predisposition with both calcification in the aortic arch and the carotid arteries, providing novel insights into the etiology of atherosclerosis.
Daniel Bos; M Arfan Ikram; Aaron Isaacs; Benjamin F J Verhaaren; Albert Hofman; Cornelia M van Duijn; Jacqueline C M Witteman; Aad van der Lugt; Meike W Vernooij
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-16
Journal Detail:
Title:  Circulation. Cardiovascular genetics     Volume:  -     ISSN:  1942-3268     ISO Abbreviation:  Circ Cardiovasc Genet     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101489144     Medline TA:  Circ Cardiovasc Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Erasmus MC, Rotterdam, the Netherlands.
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