Document Detail


Genetic Liability to Schizophrenia Measured by P300 in Concordant and Discordant Monozygotic Twins.
MedLine Citation:
PMID:  21968749     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Differential effects of genes and environment can contribute to etiological heterogeneity in schizophrenia. Twins concordant and discordant for schizophrenia may differ in genetic predisposition to schizophrenia with concordant twins having a higher genetic liability and discordant twins having a lower genetic liability to schizophrenia. We aimed to investigate whether P300 amplitude (which has been postulated as a genetic marker for schizophrenia) reflected this heterogeneity. Sampling and Methods: We compared P300 amplitudes across 36 monozygotic twin pairs (6 concordant for schizophrenia/schizoaffective disorder, 11 discordant and 19 healthy control pairs) performing an auditory oddball task, using multiple regression (age, gender, birth order, premorbid IQ as covariates). We further looked at the correlation between the Brief Psychiatric Rating Scale (BPRS) and P300 amplitude in affected twins, and compared concordant and discordant affected twins on the Global Assessment Scale (GAS). Results: Multiple regression yielded a highly significant model (p = 0.004) though the explained variance was limited (21%). The main effect of the group on P300 amplitude was significant (p = 0.0001): affected concordant twins showed a significantly lower P300 amplitude as compared to affected discordant (p = 0.005, Cohen's d = 1.08) and control twins (p = 0.000, d = 1.16). Discordant affected and unaffected twins did not differ significantly from each other or from control twins. P300 did not correlate significantly with the BPRS and the affected groups did not differ across the GAS. Conclusions: Our results provide evidence for etiological heterogeneity within schizophrenia pointing to different pathophysiological mechanisms that may underlie more and less genetically determined forms of schizophrenia. They also indicate that P300 correlates with a differing degree of genetic liability to schizophrenia independently of the psychopathological status and even in the presence of similar functional profiles.
Authors:
Anuradha Sharma; Heinrich Sauer; Dirk J A Smit; Stephan Bender; Matthias Weisbrod
Related Documents :
22187409 - Inherited risk factors for thrombotic diseases in children: the genome-wide perspective.
21656579 - A single-nucleotide polymorphism in tumor suppressor gene sel1l as a predictive and pro...
207669 - Arginine auxotrophic phenotype of mutation in pyra of salmonella typhimurium: role of n...
21717509 - Bioinformatic analyses to select phenotype affecting polymorphisms in htr2c gene.
21655939 - Association between mannose-binding lectin and interleukin-1 receptor antagonist gene p...
22100839 - Distribution of mica haplotypes in a chinese han population.
24058439 - The opportunistic pathogen propionibacterium acnes: insights into typing, human disease...
22772479 - Mutation analysis of gm1 gangliosidosis in a siamese cat from japan in the 1960s.
25073639 - The effect of the 'gait keeper' mutation in the dmrt3 gene on gaiting ability in icelan...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-29
Journal Detail:
Title:  Psychopathology     Volume:  44     ISSN:  1423-033X     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-10-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8401537     Medline TA:  Psychopathology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  398-406     Citation Subset:  -    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
Department of General Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A simplified method for the generation of human osteoclasts in vitro.
Next Document:  Obstructive Sleep Apnea: The Most Common Secondary Cause of Hypertension Associated With Resistant H...