Document Detail


Genetic Evidence That Lipoprotein(a) Associates With Atherosclerotic Stenosis Rather Than Venous Thrombosis.
MedLine Citation:
PMID:  22516069     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: The aim of the present study was to determine whether lipoprotein(a) [Lp(a)], considered a causal risk factor for cardiovascular disease, primarily promotes thrombosis or atherosclerosis. METHODS AND RESULTS: Using a Mendelian randomization study design, we measured plasma Lp(a) and genetically elevated Lp(a) levels through the LPA kringle IV type 2 repeat genotype in 41 231 individuals. We included 2 general population studies of both venous thrombosis and combined thrombosis and atherosclerosis in coronary arteries (=myocardial infarction), and 3 case-control studies of atherosclerotic stenosis. Neither Lp(a) tertiles nor LPA kringle IV type 2 tertiles associated with the risk of venous thrombosis in general population studies (trend: P=0.12-0.76), but did each associate with risk of coronary, carotid, and femoral atherosclerotic stenosis in case-control studies (trend: P<0.001 to 0.04). Lp(a) and LPA kringle IV type 2 tertiles also associated with the risk of myocardial infarction in general population studies (trend: P<0.001 to 0.003). For doubling of Lp(a) levels, instrumental variable estimates of hazard/odds ratios were 1.02 (95% CI 0.90-1.15) and 1.04 (0.93-1.16) for venous thrombosis in the 2 general population studies, 1.12 (1.01-1.25), 1.17 (1.05-1.32), and 1.16 (1.01-1.35), respectively, for coronary, carotid, and femoral atherosclerotic stenosis in case-control studies, and 1.21 (1.10-1.33) and 1.17 (1.05-1.29) for myocardial infarction in general population studies. CONCLUSIONS: This supports that Lp(a) primarily promotes atherosclerotic stenosis rather than venous thrombosis.
Authors:
Pia R Kamstrup; Anne Tybjærg-Hansen; Børge G Nordestgaard
Related Documents :
12107099 - Impaired nitric oxide-mediated flow-induced coronary dilation in hyperhomocysteinemia: ...
9350919 - Effect of l-arginine on human coronary endothelium-dependent and physiologic vasodilation.
19369689 - Increased basal myocardial perfusion in patients with chronic kidney disease without sy...
20546779 - Therapeutic advances in myocardial microvascular resistance: unravelling the enigma.
11214429 - Cardiovascular diseases and nitric oxide in humans.
15085069 - Methotrexate and mx-68, a new derivative of methotrexate, limit infarct size via adenos...
3125669 - Effects of verapamil and timolol on cellular morphometric changes in cat hearts with re...
16342349 - Levosimendan as a new strategy during off-pump coronary artery bypass grafting: double-...
17967979 - Metabolic profiling of arginine and nitric oxide pathways predicts hemodynamic abnormal...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-19
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  -     ISSN:  1524-4636     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Thioredoxin-1 Promotes Anti-Inflammatory Macrophages of the M2 Phenotype and Antagonizes Atheroscler...
Next Document:  Thrombus growth and embolism on tissue factor-bearing collagen surfaces under flow: role of thrombin...