Document Detail

Genetic Epidemiology of Tooth Agenesis in Japan: A Population-and Family-based Study.
MedLine Citation:
PMID:  25041097     Owner:  NLM     Status:  Publisher    
Tooth agenesis is one of the most common congenital anomalies in humans. However, the etiology of tooth agenesis remains largely unclear, as well as evidence base useful for genetic counseling. Therefore, we estimated the prevalence and sibling recurrence risk, and investigated agenetic patterns systematically. Tooth agenesis was classified into two subtypes: hypodontia (one to five missing teeth) and oligodontia (six or more missing teeth). The prevalence of these two subtypes were 6.8% (95% CI: 6.1 to 7.7%) and 0.1% (95% CI: 0.04 to 0.3%), respectively, and sibling recurrence risk of these were 24.5 (95% CI: 13.8 to 38.3%) and 43.8% (95% CI: 26.4 to 62.3%), respectively. This result suggests that the severe phenotype, oligodontia, might be mostly transmitted in a dominant fashion. Using a simple statistical modeling approach, our data were found to be consistent with a bilateral symmetry model, meaning that there was equal probability of missing teeth from the right and left sides.
Junichiro Machida; Takeshi Nishiyama; Hirohisa Kishino; Seishi Yamaguchi; Masashi Kimura; Akio Shibata; Tadashi Tatematsu; Munefumi Kamamoto; Keiichi Yamamoto; Shinya Makino; Hitoshi Miyachi; Kazuo Shimozato; Yoshihito Tokita
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-7
Journal Detail:
Title:  Clinical genetics     Volume:  -     ISSN:  1399-0004     ISO Abbreviation:  Clin. Genet.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0253664     Medline TA:  Clin Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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