Document Detail


Clinical review 2: Genetic determinants of bone density and fracture risk--state of the art and future directions.
MedLine Citation:
PMID:  20375209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: Osteoporosis is a common, highly heritable condition that causes substantial morbidity and mortality, the etiopathogenesis of which is poorly understood. Genetic studies are making increasingly rapid progress in identifying the genes involved.
EVIDENCE ACQUISITION AND SYNTHESIS: In this review, we will summarize the current understanding of the genetics of osteoporosis based on publications from PubMed from the year 1987 onward.
CONCLUSIONS: Most genes involved in osteoporosis identified to date encode components of known pathways involved in bone synthesis or resorption, but as the field progresses, new pathways are being identified. Only a small proportion of the total genetic variation involved in osteoporosis has been identified, and new approaches will be required to identify most of the remaining genes.
Authors:
Emma L Duncan; Matthew A Brown
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-04-07
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  95     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-07     Completed Date:  2010-07-01     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2576-87     Citation Subset:  AIM; IM    
Affiliation:
University of Queensland Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Queensland 4102, Australia. e.duncan@uq.edu.au
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MeSH Terms
Descriptor/Qualifier:
Bone Density / genetics*
Female
Fractures, Bone / epidemiology*,  genetics*
Gene Frequency
Genetic Linkage
Genome-Wide Association Study
Humans
Male
Osteoporosis / epidemiology,  genetics
Phenotype
Risk

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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