| Genetic counseling considerations in the evaluation of families for lynch syndrome-a review. | |
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MedLine Citation:
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PMID: 20931355 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Lynch syndrome is the most common hereditary colorectal cancer syndrome and the most common cause of hereditary endometrial cancer. Identifying and evaluating families for Lynch syndrome is increasing in complexity due to the recognition that: family history-based clinical criteria lack sensitivity and specificity; genetic testing for Lynch syndrome continues to evolve as understanding of the molecular mechanisms underlying it evolves; and the Lynch syndrome phenotype encompasses multiple organ systems and demonstrates overlap with other hereditary cancer syndromes. This document is a summary of considerations when evaluating individuals and families for Lynch syndrome, including information on cancer risks, diagnostic criteria, tumor and genetic testing strategies, and the management of individuals with this condition. |
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Authors:
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Scott M Weissman; Cecelia Bellcross; Christina Chimera Bittner; Mary E Freivogel; Joy Larsen Haidle; Pardeep Kaurah; Anna Leininger; Selvi Palaniappan; Kelle Steenblock; Thuy M Vu; Molly S Daniels |
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Publication Detail:
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Type: Journal Article Date: 2010-10-08 |
Journal Detail:
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Title: Journal of genetic counseling Volume: 20 ISSN: 1573-3599 ISO Abbreviation: J Genet Couns Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9206865 Medline TA: J Genet Couns Country: United States |
Other Details:
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Languages: eng Pagination: 5-19 Citation Subset: IM |
Affiliation:
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Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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