| Genetic Analysis of Atherosclerosis and Glucose Homeostasis in an Intercross Between C57BL/6 and BALB/cJ Apolipoprotein E-Deficient Mice. | |
| | |
MedLine Citation:
|
PMID: 22294616 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: -Diabetic patients have an increased risk of developing atherosclerosis and related complications compared to non-diabetic individuals. The increased cardiovascular risk associated with diabetes is due in part to genetic variations that influence both glucose homeostasis and atherosclerotic lesion growth. Mouse strains C57BL/6J (B6) and BALB/cJ (BALB) exhibit distinct differences in fasting plasma glucose and atherosclerotic lesion size when deficient in apolipoprotein E (Apoe(-/-)). Quantitative trait locus (QTL) analysis was performed to determine genetic factors influencing the two phenotypes. METHODS AND RESULTS: -266 female F(2) mice were generated from an intercross between B6.Apoe(-/-) and BALB.Apoe(-/-) mice and fed a Western diet for 12 weeks. Atherosclerotic lesions in the aortic root, fasting plasma glucose, and body weight were measured. 130 microsatellite markers across the entire genome were genotyped. Four significant QTLs, Ath1 on chromosome (Chr) 1, Ath41 on Chr2, Ath42 on Chr5, and Ath29 on Chr9, and one suggestive QTL on Chr4, were identified for atherosclerotic lesion size. Four significant QTLs, Bglu3 and Bglu12 on Chr1, Bglu13 on Chr5, Bglu15 on Chr12, and two suggestive QTLs on Chr9 and Chr15 were identified for fasting glucose levels on the chow diet. Two significant QTLs, Bglu3 and Bglu13, and one suggestive locus on Chr8 were identified for fasting glucose on the Western diet. One significant locus on Chr1 and two suggestive loci on Chr9 and Chr19 were identified for body weight. Ath1 and Ath42 coincided with Bglu3 and Bglu13, respectively, in the confidence interval. CONCLUSIONS: -We have identified novel QTLs that have major influences on atherosclerotic lesion size and glucose homeostasis. The colocalization of QTLs for atherosclerosis and diabetes suggests possible genetic connections between the two diseases. |
| | |
Authors:
|
Zhimin Zhang; Jessica S Rowlan; Qian Wang; Weibin Shi |
Related Documents
:
|
425996 - Pancreatic venography and plasma ketone measurements in the diagnosis of hyperinsulinism. 2442746 - Immunohisto- and cytochemical studies of pancreatic enzymes in peri-insular and tele-in... 15513386 - Targeted inhibition of gene expression of pancreatitis-associated proteins exacerbates ... 3177646 - Cholecystokinin in the regulation of intestinal motility and pancreatic secretion in dogs. 857576 - Ultrastructure of muscle biopsies in recent, short-term and long-term juvenile diabetes. 21898126 - Miglitol administered before breakfast increased plasma active glucagon-like peptide-1 ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-31 |
Journal Detail:
|
Title: Circulation. Cardiovascular genetics Volume: - ISSN: 1942-3268 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-2-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101489144 Medline TA: Circ Cardiovasc Genet Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
University of Virginia, Charlottesville, VA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Left Atrial Wall Stress Distribution and Its Relationship to Electrophysiologic Remodeling in Persis...
Next Document: Loss of Abaxial Leaf Epicuticular Wax in Medicago truncatula irg1/palm1 Mutants Results in Reduced S...