Document Detail

Genesis and systematization of cardiovascular anomalies in murine trisomy 16.
MedLine Citation:
PMID:  1838186     Owner:  NLM     Status:  MEDLINE    
On account of genetic homologies trisomy 16 in the mouse is regarded as an animal model of Down's syndrome. A detailed evaluation of the cardiovascular system in 109 fetuses with trisomy 16 and 422 balanced siblings was performed in order to systematize the cardiovascular anomalies and to elucidate the pathogenetic mechanisms responsible for their formation. 92% of fetuses with experimentally induced trisomy 16 exhibited cardiovascular anomalies. The most common types of anomalies were hypoplasia and aplasia of the aortic arch, which appeared in 85% of the fetuses. Situs inversus of the aortic arch system was remarkably frequent (20%). Hypoplasia or aplasia of the pulmonary artery was seen in 10% of the fetuses. A too proximal insertion of the pulmonary artery into the ascending aorta was observed in 8% of the fetuses.
W Buselmaier; C Bacchus; H Sterz
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Progress in clinical and biological research     Volume:  373     ISSN:  0361-7742     ISO Abbreviation:  Prog. Clin. Biol. Res.     Publication Date:  1991  
Date Detail:
Created Date:  1992-03-10     Completed Date:  1992-03-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7605701     Medline TA:  Prog Clin Biol Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  203-14     Citation Subset:  IM    
Institute for Human Genetics and Anthropology, University of Heidelberg, Federal Republic of Germany.
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MeSH Terms
Aorta, Thoracic / abnormalities
Disease Models, Animal
Down Syndrome / complications*
Heart Defects, Congenital / etiology*
Pulmonary Artery / abnormalities

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