Document Detail

Genesis of medical thromboprophylaxis guidelines in Australia: a need for transparency and standardisation in guideline development.
MedLine Citation:
PMID:  19374619     Owner:  NLM     Status:  MEDLINE    
Clinical guidelines are recommendations based on systematic identification and synthesis of the best available scientific evidence. The National Health and Medical Research Council (NHMRC) has published standards for guideline development. According to the NHMRC standards, guideline development must be a transparent and independent process, with full disclosure of any potential competing interests. Australian guidelines for prevention of venous thromboembolism have been published by an autonomous group. Several features of the processes used to produce and distribute these guidelines, such as pharmaceutical sponsorship, do not meet NHMRC endorsement standards. The guidelines may overstate the need for thrombo-prophylaxis in medical patients, and thus expose some patients to an unnecessary risk of bleeding complications. Despite this, these guidelines have been taken up avidly by national and state bodies responsible for safety and quality in health care, and mandated national application has been proposed.
J Alasdair Millar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Medical journal of Australia     Volume:  190     ISSN:  0025-729X     ISO Abbreviation:  Med. J. Aust.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-20     Completed Date:  2009-07-29     Revised Date:  2009-09-01    
Medline Journal Info:
Nlm Unique ID:  0400714     Medline TA:  Med J Aust     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  446-50; discussion 450     Citation Subset:  IM    
Royal Perth Hospital, Perth, WA.
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MeSH Terms
Conflict of Interest
Drug Industry*
Fibrinolytic Agents / therapeutic use*
Heparin / therapeutic use*
Interprofessional Relations*
Practice Guidelines as Topic*
Publication Bias
Thrombolytic Therapy*
Reg. No./Substance:
0/Fibrinolytic Agents; 9005-49-6/Heparin
Comment In:
Med J Aust. 2009 Apr 20;190(8):407-8   [PMID:  19374610 ]
Med J Aust. 2009 Aug 3;191(3):189-90   [PMID:  19645656 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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