| Genesis of the decrement of intraluminal pressure in the UES during swallowing in rabbits. | |
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MedLine Citation:
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PMID: 15862797 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The intraluminal pressure in the upper esophageal sphincter (UES) briefly decreases during swallowing. This decrement in pressure plays an important role in smooth transport of the ingested bolus from the pharynx to the esophagus. It is known that the decrement is caused by cessation of tonic activity of the cricopharyngeus (CP) muscle and also by elevation of the larynx. On the other hand, it is suspected that the recurrent laryngeal nerve (RLN) also contributes to the decrement, since our preliminary study showed for the first time that the decrement in UES pressure was much reduced after the RLN was sectioned. In the present study, we examined the genesis of the decrement of the UES pressure in anesthetized rabbits. When swallowing was elicited by repetitive electrical stimulation of the superior laryngeal nerve, the UES pressure briefly decreased and then abruptly increased. After bilateral sectioning of the RLN, the decrement of the pressure was significantly reduced, whereas the increment was little altered. Sectioning of the pharyngeal branch of the vagus nerve (X-ph) and the RLN mostly eliminated both the decrement and increment of the pressure, and abolished tonic and burst activities of the CP muscle. Electrical stimulation of peripheral end of the RLN decreased the pressure. These results indicate that the RLN and X-ph are involved in the decrement of the UES pressure during swallowing. The RLN generates the decrement by adducting the arytenoid cartilage and closing the glottis. The X-ph contributes to the decrement both by suppressing the tonic activity of the CP muscle and by regulating the laryngeal elevation. |
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Authors:
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Shin-Ichi Fukushima; Tomio Shingai; Yoshihiro Takahashi; Yo Taguchi; Tadashi Noda; Yoshiaki Yamada |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2005-04-07 |
Journal Detail:
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Title: Brain research Volume: 1044 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-05-02 Completed Date: 2005-07-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 122-6 Citation Subset: IM |
Affiliation:
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Division of Pediatric Dentistry, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Niigata 951-8514, Japan. fukuchan@dent.niigata-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Deglutition / physiology* Electric Stimulation / methods Electromyography / methods Esophageal Sphincter, Upper / physiology*, radiation effects Laryngeal Nerves / physiology*, radiation effects Male Pressure* Rabbits |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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