| Genes within the major histocompatibility complex predict NIDDM in African-American women in Alabama. | |
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MedLine Citation:
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PMID: 7882825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To test the hypothesis that genes within the major histocompatibility complex (MHC) are associated with gestational diabetes mellitus (GDM) and, subsequently, non-insulin-dependent diabetes mellitus (NIDDM) in African-American women. RESEARCH DESIGN AND METHODS: African-American women who presented with GDM were compared with pregnant African-American control subjects. Following pregnancy, GDM patients were assessed at various intervals of time (median = 6 years) to determine whether they had developed diabetes. RESULTS: GDM patients who required insulin during pregnancy possessed a significantly higher frequency of A33, DR2, DR9, and BF-S phenotypes than control subjects. GDM patients who subsequently developed NIDDM had a significantly higher frequency of B41, DR2, and BF-S and a lower frequency of DR1 and DR6 phenotypes than control subjects. Even after controlling for age and body mass index, B41 and DR2 were independent predictors of developing insulin-requiring GDM and NIDDM in GDM subjects. CONCLUSIONS: These results suggest that either one or more genes within the MHC are involved in the etiology of NIDDM. |
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Authors:
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R T Acton; J M Roseman; D S Bell; R L Goldenberg; M L Tseng; C Vanichanan; L A Harman; R C Go |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Diabetes care Volume: 17 ISSN: 0149-5992 ISO Abbreviation: Diabetes Care Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-04-12 Completed Date: 1995-04-12 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1491-4 Citation Subset: IM |
Affiliation:
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Department of Microbiology, University of Alabama at Birmingham. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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African Continental Ancestry Group
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genetics* Alabama Cohort Studies Diabetes Mellitus, Type 2 / genetics* Diabetes, Gestational / genetics* Female Genes, MHC Class I / genetics* Genes, MHC Class II / genetics* HLA Antigens / genetics HLA-B Antigens / genetics Humans Hypertension / complications Phenotype Pregnancy Retrospective Studies |
| Grant Support | |
ID/Acronym/Agency:
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DK-32767/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens; 0/HLA-B Antigens; 0/HLA-B67 antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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