Document Detail


Genes involved in conceptus-endometrial interactions in ruminants: insights from reductionism and thoughts on holistic approaches.
MedLine Citation:
PMID:  18239047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This review summarizes new knowledge on expression of genes and provides insights into approaches for study of conceptus-endometrial interactions in ruminants with emphasis on the peri-implantation stage of pregnancy. Conceptus-endometrial interactions in ruminants are complex and involve carefully orchestrated temporal and spatial alterations in gene expression regulated by hormones from the ovary and conceptus. Progesterone is the hormone of pregnancy and acts on the uterus to stimulate blastocyst survival, growth, and development. Inadequate progesterone levels or a delayed rise in progesterone is associated with pregnancy loss. The mononuclear trophectoderm cells of the elongating blastocyst synthesize and secrete interferon-tau (IFNT), the pregnancy recognition signal. Trophoblast giant binucleate cells begin to differentiate and produce hormones including chorionic somatomammotropin 1 (CSH1 or placental lactogen). A number of genes, induced or stimulated by progesterone, IFNT, and/or CSH1 in a cell-specific manner, are implicated in trophectoderm adhesion to the endometrial luminal epithelium and regulation of conceptus growth and differentiation. Transcriptional profiling experiments are beginning to unravel the complex dynamics of conceptus-endometrial interactions in cattle and sheep. Future experiments should incorporate physiological models of pregnancy loss and be complemented by metabolomic studies of uterine lumen contents to more completely define factors required for blastocyst survival, growth, and implantation. Both reduction and holistic approaches will be important to understand the multifactorial phenomenon of recurrent pregnancy loss and provide a basis for new strategies to improve pregnancy outcome and reproductive efficiency in cattle and other domestic animals.
Authors:
Thomas E Spencer; Olivier Sandra; Eckhard Wolf
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  135     ISSN:  1470-1626     ISO Abbreviation:  Reproduction     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-01     Completed Date:  2008-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  England    
Other Details:
Languages:  eng     Pagination:  165-79     Citation Subset:  IM    
Affiliation:
Department of Animal Science, Center for Animal Biotechnology and Genomics, Texas A&M University, College Station, Texas 77843, USA. tspencer@tamu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Embryo Implantation / genetics*
Female
Gene Expression Profiling
Gene Expression Regulation, Developmental*
Oligonucleotide Array Sequence Analysis
Pregnancy
Pregnancy Maintenance / genetics
Pregnancy, Animal / genetics*
Ruminants / embryology*,  genetics
Sheep

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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