| Genes in the ear: what have we learned over the last years? | |
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MedLine Citation:
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PMID: 11409777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In developed countries 50% of childhood hearing impairment is attributable to genetic causes. In a limited number of cases, the hearing impairment is part of a syndrome, and several genes for syndromic deafness have been identified over the last 10 years. In the majority of cases, the hearing impairment occurs without additional clinical abnormalities (non-syndromic). Progressive hearing loss is very frequent in adults. By the age of 80 approximately 50% of the population is affected by age-related hearing loss, which is due partly to genetic factors. Before 1994, little was known about the genes responsible for non-syndromic hearing impairment, although epidemiological studies have suggested that more than 100 genes might be involved. Over the last 6 years, extremely rapid progress was realized in the field of the molecular genetics of hearing and deafness. More than 70 genes for non-syndromic hearing impairment have been localized to the human genome, and 18 of these have been identified. |
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Authors:
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L Van Laer; G Van Camp |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Scandinavian audiology. Supplementum Volume: - ISSN: 0107-8593 ISO Abbreviation: Scand Audiol Suppl Publication Date: 2001 |
Date Detail:
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Created Date: 2001-06-18 Completed Date: 2001-12-28 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0325221 Medline TA: Scand Audiol Suppl Country: Denmark |
Other Details:
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Languages: eng Pagination: 44-53 Citation Subset: IM |
Affiliation:
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Department of Medical Genetics, University of Antwerp, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Gene Expression
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genetics Hearing Disorders / diagnosis, epidemiology*, genetics* Humans Incidence |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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