| Genes expressed in neurons of adult male Drosophila. | |
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MedLine Citation:
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PMID: 9038337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have identified two genes, roX1 and roX2, whose expression in the adult fly is restricted to neurons of males. The two genes reside on the X chromosome, and each encodes an RNA with no apparent open reading frame. Both genes are physically linked to female-specific genes that encode proteins expressed in the ovary: opt1, a novel peptide transporter, and nod, a member of the kinesin family. The male-specific transcripts are positively regulated by the dosage compensation pathway in an all-or-none fashion. Our data suggest that the multimeric complex of dosage compensation proteins may operate in different ways on different sets of X-linked genes. |
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Authors:
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H Amrein; R Axel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cell Volume: 88 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 1997 Feb |
Date Detail:
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Created Date: 1997-03-17 Completed Date: 1997-03-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 459-69 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/U85980; U85981; U85982 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Brain / cytology DNA, Complementary / analysis Drosophila Proteins* Drosophila melanogaster / genetics* Female Ganglia, Invertebrate / cytology Gene Dosage Gene Expression / physiology Gene Expression Regulation, Developmental / physiology Gene Library Genes, Insect / physiology* Insect Hormones / genetics Linkage (Genetics) Male Molecular Sequence Data Neurons / physiology* Nuclear Proteins / genetics Peripheral Nervous System / cytology RNA, Messenger / analysis, physiology RNA-Binding Proteins / genetics Sequence Homology, Amino Acid Sex Determination (Analysis) Transcription, Genetic / physiology X Chromosome Y Chromosome |
| Grant Support | |
ID/Acronym/Agency:
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CA 23767/CA/NCI NIH HHS; NS 29832/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA, Complementary; 0/Drosophila Proteins; 0/Insect Hormones; 0/Nuclear Proteins; 0/RNA, Messenger; 0/RNA-Binding Proteins; 0/Rox2 protein, Drosophila; 0/transformer protein, Drosophila |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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