| Generic substitution of antiepileptic drugs. | |
| | |
MedLine Citation:
|
PMID: 21091318 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Substitution of antiepileptic drugs with generic formulations may affect individual people, as well as healthcare systems. Analyses of large medical claims databases suggest that generic substitution of antiepileptic drugs is associated with increased morbidity and greater use of healthcare resources. While a single brand-to-generic switch may be associated with a slight increase in overall medical costs, multiple switches may be associated with higher costs, perhaps because different generic agents are not required to be bioequivalent to each other. Generic substitution also affects the individual: along with the possible increased risk of seizures or adverse events, inconsistency of supply may make the medication appear unfamiliar, thus discouraging adherence. Importantly, substitution is often carried out at the dispensing level, without the knowledge or consent of physicians and affected individuals. Therefore, regulatory and professional bodies advocate that substitution should not be carried out without specific counseling of the individual by healthcare professionals on the details and implications of the change. |
| | |
Authors:
|
Josemir W Sander; Philippe Ryvlin; Hermann Stefan; Daniel R Booth; Jürgen Bauer |
Related Documents
:
|
15765268 - Pharmacotherapy of parkinson's disease in germany. 17482108 - Obesity and litigation predict workers' compensation costs associated with interbody ca... 9450118 - Highway crash costs in the united states by driver age, blood alcohol level, victim age... 19725798 - Cost of illness associated with niemann-pick disease type c in the uk. 21320108 - Cesare lombroso and epilepsy 100 years later: an unabridged report of his original tr... 22256268 - Using support vector machines to detect medical fraud and abuse. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Expert review of neurotherapeutics Volume: 10 ISSN: 1744-8360 ISO Abbreviation: Expert Rev Neurother Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101129944 Medline TA: Expert Rev Neurother Country: England |
Other Details:
|
Languages: eng Pagination: 1887-98 Citation Subset: IM |
Affiliation:
|
UCL Institute for Neurology, University College London, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Electroencephalographic assessment of patients with epileptic seizures.
Next Document: Persistence of High Blood Levels of the Chemokines CCL2, CCL19, and CCL20 During the Course of HIV I...