Document Detail

Generator-produced rubidium-82 positron emission tomography myocardial perfusion imaging-From basic aspects to clinical applications.
MedLine Citation:
PMID:  20206068     Owner:  NLM     Status:  MEDLINE    
Cardiovascular disease is the leading cause of death in modern industrialized countries with an aging population. This fact has fueled the need for innovative diagnostic testing intended to improve coronary artery disease (CAD) patient care. Detection of myocardial ischemia using myocardial perfusion imaging (MPI) plays an important role for CAD diagnosis and the prediction of future risk of cardiovascular events. Positron emission tomography (PET) MPI has high diagnostic accuracy and can estimate regional myocardial blood flow (MBF) in patients with CAD. Rubidium-82 ((82)Rb) is a generator-produced PET myocardial perfusion tracer and has been widely used in North America in clinical practice. (82)Rb PET has recently become available in some cardiovascular centers in Europe and Japan. Clinical trials are expected in both regions. (82)Rb PET has high diagnostic accuracy and recent data have shown its prognostic value. Thus, (82)Rb PET would greatly contribute to CAD patients' care. (82)Rb PET can also be used to quantify MBF. This review describes the current status of (82)Rb MPI from basic principles to clinical implications. This paper also highlights the recent development of MBF quantification using (82)Rb PET.
Keiichiro Yoshinaga; Ran Klein; Nagara Tamaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-02-08
Journal Detail:
Title:  Journal of cardiology     Volume:  55     ISSN:  0914-5087     ISO Abbreviation:  J Cardiol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-08-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  163-73     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
Department of Molecular Imaging, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-Ku, Sapporo, Hokkaido 060-8638, Japan.
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MeSH Terms
Coronary Disease / radionuclide imaging*
Positron-Emission Tomography / methods*
Rubidium Radioisotopes / diagnostic use*
Reg. No./Substance:
0/Rubidium Radioisotopes

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