Document Detail


Generation of unidirectionally propagating action potentials using a monopolar electrode cuff.
MedLine Citation:
PMID:  3789489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Unidirectionally propagating action potentials, which can be used to implement transmission failure on peripheral nerve through "collision block," have been generated electrically on cat myelinated peripheral nerve using a monopolar electrode cuff with the conductor positioned closest to the "arrest" end of the cuff. A single cathode located at least 5 mm from the arrest end resulted in unidirectional propagation with minimal current and charge injection. The range of stimulus current values that produced unidirectional propagation increased with increases in longitudinal asymmetry of cathode placement over the range of asymmetries tested (1.7:1 to 7:1). The stimulus current pulse that minimized charge injection was quasitrapezoidal in shape with a plateau pulse width of approximately 350 microseconds and an exponential trailing phase having a fall time (90%-10%) of approximately 600 microseconds These parameters were found to be independent of cuff geometry. Arrest efficiency was not degraded using a cuff of sufficient internal diameter to prevent nerve compression in chronic implantation. The critical current density within the extracellular space of the electrode cuff required to produce conduction failure at the arrest end was estimated to be 0.47 +/- 0.08 mA/mm2.
Authors:
I J Ungar; J T Mortimer; J D Sweeney
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  14     ISSN:  0090-6964     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  1986  
Date Detail:
Created Date:  1986-12-24     Completed Date:  1986-12-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  437-50     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Action Potentials*
Animals
Cats
Electrodes
Electrophysiology
Peripheral Nerves / physiology*
Grant Support
ID/Acronym/Agency:
HL075-35/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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