| Generation of reelin-positive marginal zone cells from the caudomedial wall of telencephalic vesicles. | |
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MedLine Citation:
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PMID: 14999079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An early and fundamental step of the laminar organization of developing neocortex is controlled by the developmental programs that critically depend on the activities of reelin-positive cells in the marginal zone. However, the ontogeny of reelin-positive cells remained elusive. To gain insights into the spatial and temporal regulation of reelin-positive marginal zone cell development, we used a transgenic mouse line in which we defined the green fluorescent protein (GFP) transgene as a novel reliable molecular marker of reelin-positive marginal zone cells from the early stages of their development. We further used exo utero electroporation-mediated gene transfer that allows us to mark progenitor cells and monitor the descendants in the telencephalon in vivo. We show here the generation of reelin-positive marginal zone cells from the caudomedial wall of telencephalic vesicles, including the cortical hem, where the prominent expression of GFP is initially detected. These neurons tangentially migrate at the cortical marginal zone and are distributed throughout the entire neocortex in a caudomedial-high to rostrolateral-low gradient during the dynamic developmental period of corticogenesis. Therefore, our findings on reelin-positive marginal zone cells, in addition to the cortical interneurons, add to the emerging view that the neocortex consists of neuronal subtypes that originate from a focal source extrinsic to the neocortex, migrate tangentially into the neocortex, and thereby underlie neural organization of the neocortex. |
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Authors:
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Keiko Takiguchi-Hayashi; Mariko Sekiguchi; Shizuko Ashigaki; Masako Takamatsu; Hiroshi Hasegawa; Rika Suzuki-Migishima; Minesuke Yokoyama; Shigetada Nakanishi; Yasuto Tanabe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 24 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-04 Completed Date: 2004-05-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 2286-95 Citation Subset: IM |
Affiliation:
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Translational Research Department, Molecular Bio-Medicine Unit, Japan Science and Technology, Mitsubishi Kagaku Institute of Life Sciences, Machida, Tokyo, 194-8511, Japan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, Differentiation / biosynthesis Cell Adhesion Molecules, Neuronal / biosynthesis* Cell Movement / physiology* Cells, Cultured DNA-Binding Proteins / biosynthesis Electroporation Extracellular Matrix Proteins / biosynthesis* Genes, Reporter Genes, Tumor Suppressor Gestational Age Green Fluorescent Proteins Luminescent Proteins / biosynthesis, genetics Mice Mice, Inbred C57BL Mice, Inbred ICR Mice, Transgenic Neocortex / cytology, embryology, metabolism Nerve Tissue Proteins Neurons / cytology, metabolism* Nuclear Proteins / biosynthesis Serine Endopeptidases Telencephalon / cytology, embryology, metabolism* Tumor Suppressor Proteins |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Differentiation; 0/Cell Adhesion Molecules, Neuronal; 0/DNA-Binding Proteins; 0/Extracellular Matrix Proteins; 0/Luminescent Proteins; 0/Nerve Tissue Proteins; 0/Nuclear Proteins; 0/Tumor Suppressor Proteins; 0/tumor suppressor protein p73; 147336-22-9/Green Fluorescent Proteins; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.-/reelin protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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