| Generation of pluripotent stem cells from patients with type 1 diabetes. | |
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MedLine Citation:
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PMID: 19720998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic beta cells. The cellular and molecular defects that cause the disease remain unknown. Pluripotent cells generated from patients with T1D would be useful for disease modeling. We show here that induced pluripotent stem (iPS) cells can be generated from patients with T1D by reprogramming their adult fibroblasts with three transcription factors (OCT4, SOX2, KLF4). T1D-specific iPS cells, termed DiPS cells, have the hallmarks of pluripotency and can be differentiated into insulin-producing cells. These results are a step toward using DiPS cells in T1D disease modeling, as well as for cell replacement therapy. |
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Authors:
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René Maehr; Shuibing Chen; Melinda Snitow; Thomas Ludwig; Lisa Yagasaki; Robin Goland; Rudolph L Leibel; Douglas A Melton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-31 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 106 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-10-06 Completed Date: 2009-11-13 Revised Date: 2011-09-02 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 15768-73 Citation Subset: IM |
Affiliation:
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Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Adult Stem Cells / metabolism, pathology*, transplantation Cell Dedifferentiation Cell Differentiation Cells, Cultured Diabetes Mellitus, Type 1 / metabolism, pathology*, therapy Endoderm / cytology, metabolism Germ Layers / cytology, metabolism Humans Male Models, Biological Pancreas / cytology Pluripotent Stem Cells / metabolism, pathology*, transplantation Transcription Factors / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK052431-17/DK/NIDDK NIH HHS; R01 DK052431-18/DK/NIDDK NIH HHS; R01 DK052431-19/DK/NIDDK NIH HHS; R01 DK066518-08/DK/NIDDK NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/Transcription Factors |
| Comments/Corrections | |
Comment In:
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Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15523-4
[PMID:
19805208
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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