Document Detail

Generation of multiple cell types in Bacillus subtilis.
MedLine Citation:
PMID:  19054118     Owner:  NLM     Status:  MEDLINE    
Bacillus subtilis is a Gram-positive bacterium that is well known for its ability to differentiate into metabolically inactive spores that are highly resistant to environmental stresses. In fact, populations of genetically identical B. subtilis comprise numerous distinct cell types. In addition to spores, cells can become genetically competent, motile, produce extracellular matrix or degradative enzymes, or secrete toxins that allow them to cannibalize their neighbors. Many of the cell fates listed above appear to be mutually exclusive. In this review, we discuss how individual cells within a population control their gene expression to ensure that proper regulation of differentiation occurs. These different cell fates are regulated by an intricate network that relies primarily on the activity of three major transcriptional regulators: Spo0A, DegU, and ComK. While individual cells must choose distinct cell fates, the population as a whole exhibits a spectrum of phenotypes whose diversity may increase fitness.
Daniel Lopez; Hera Vlamakis; Roberto Kolter
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-11-19
Journal Detail:
Title:  FEMS microbiology reviews     Volume:  33     ISSN:  0168-6445     ISO Abbreviation:  FEMS Microbiol. Rev.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902526     Medline TA:  FEMS Microbiol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  152-63     Citation Subset:  IM    
Department of Microbiology, Harvard Medical School, Boston, MA, USA.
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MeSH Terms
Bacillus subtilis / cytology*,  genetics,  physiology
Bacterial Proteins / genetics,  metabolism
Gene Expression Regulation, Bacterial*
Spores, Bacterial / cytology*,  genetics,  physiology
Reg. No./Substance:
0/Bacterial Proteins

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