Document Detail

Generation of immunogenic and tolerogenic clinical-grade dendritic cells.
MedLine Citation:
PMID:  22105838     Owner:  NLM     Status:  MEDLINE    
Immunotherapy with dendritic cells (DCs), which have been manipulated ex vivo to become immunogenic or tolerogenic, has been tested in clinical trials for disease therapy. DCs are sentinels of the immune system, which after exposure to antigenic or inflammatory signals and crosstalk with effector CD4(+) T cells express high levels of costimulatory molecules and cytokines. Upregulation of either costimulatory molecules or cytokines promotes immunologic DCs, whereas their downregulation generates tolerogenic DCs (TDCs), which induce T regulatory cells (Tregs) and a state of tolerance. Immunogenic DCs are used for the therapy of infectious diseases such as HIV-1 and cancer, whereas tolerogenic DCs are used in treating various autoimmune diseases and in transplantation. DC vaccination is still at an early stage, and improvements are mainly needed in quality control of monitoring assays to generate clinical-grade DC products and to assess the effect of DC vaccination in future clinical trials. Here, we review the recent work in DC generation and monitoring approaches for DC-based trials with immunogenic or tolerogenic DCs.
Tahereh Kalantari; Eskandar Kamali-Sarvestani; Bogoljub Ciric; Mohamad H Karimi; Mohsen Kalantari; Alireza Faridar; Hui Xu; Abdolmohamad Rostami
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Immunologic research     Volume:  51     ISSN:  1559-0755     ISO Abbreviation:  Immunol. Res.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-21     Completed Date:  2012-04-23     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  8611087     Medline TA:  Immunol Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  153-60     Citation Subset:  IM    
Department of Neurology, Jefferson Hospital for Neuroscience, Thomas Jefferson University, 900 Walnut Street, JHN 300, Philadelphia, PA 19107, USA.
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MeSH Terms
Antigens, CD19 / metabolism
Autoimmune Diseases / therapy
CD4-Positive T-Lymphocytes / immunology*
Cell Communication
Cell Culture Techniques
Cell Differentiation
Cell Proliferation
Cell Separation / methods*
Dendritic Cells / immunology*,  transplantation*
Immune Tolerance
Immunotherapy / methods*
Indoleamine-Pyrrole 2,3,-Dioxygenase / metabolism
Lymphocyte Activation
Neoplasms / therapy
Grant Support
Reg. No./Substance:
0/Antigens, CD19; 0/Indoleamine-Pyrrole 2,3,-Dioxygenase

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