| Generation of dyspeptic symptoms by direct acid and water infusion into the stomachs of functional dyspepsia patients and healthy subjects. | |
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MedLine Citation:
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PMID: 22085402 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background The mechanisms of the development of symptoms in functional dyspepsia (FD) patients have not been fully elucidated. We previously reported that acid directly infused into the stomach causes dyspeptic symptoms in asymptomatic healthy controls (HCs); however, the response to acid infusion of FD patients was not determined. Aim To investigate the severity of dyspeptic symptoms induced by direct acid infusion in FD subjects and HCs. Methods This was a multi-centre, cross-over, randomised, double-blind study in 23 FD subjects and 32 HCs. FD was defined using the Rome III criteria. All subjects were Helicobacter pylori negative. Each subject received two tests; 0.1 mol/L hydrochloric acid and water infused into the stomach. The presence and severity of 12 dyspeptic symptoms were assessed using a visual analogue scale. Results The proportion of subjects developing symptoms by acid or water infusion was significantly greater in FD subjects than HCs. All of the FD subjects experienced at least one symptom by water or acid infusion. In the FD subjects, the severity of symptoms was significantly greater with acid infusion than water infusion. The severity of symptoms in total and the scores for eight of the 12 symptoms induced by acid infusion was significantly greater in FD subjects than in HCs. Conclusions The severity of dyspeptic symptom generation induced by direct acid infusion into the stomach was significantly greater in functional dyspepsia subjects than in healthy controls, suggesting that hypersensitivity to acid is one of the important mechanisms of the development of symptoms in functional dyspepsia patients. |
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Authors:
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T Oshima; T Okugawa; T Tomita; J Sakurai; F Toyoshima; J Watari; K Yamaguchi; K Fujimoto; K Adachi; Y Kinoshita; H Kusunoki; K Haruma; H Miwa |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-16 |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: - ISSN: 1365-2036 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan. Department of Internal Medicine, Saga Medical School, Saga, Japan. Department of Clinical Nursing, Faculty of Medicine, Shimane University, Izumo, Japan. Department of Gastroenterology and Hepatology, Faculty of Medicine, Shimane University, Shimane, Japan. Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan. |
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