| Generation of coagulation factors V, XI, and XII by the isolated rat liver. | |
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MedLine Citation:
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PMID: 914079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When isolated rat livers were perfused with platelet-free erythrocytes suspended in Tyrode's solution containing 6% bovine serum albumin, the generation of factors V, XI, and XII was clearly demonstrable. On average, after 5 h of perfusion of a single liver, the concentrations in the perfusate (as a percentage of normal rat plasma) were about 6% for factor V, 8% for factor XI, and 5% for factor XII, compared with 20% for factor VII, which was used as the reference standard. When two livers were perfused, approximately twice these concentrations were achieved. When the properties of these factors in perfusate and plasma were compared, they agreed well except for differences in the celite adsorbability of factors XI and XII. |
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Authors:
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C A Owen; E J Bowie |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Haemostasis Volume: 6 ISSN: 0301-0147 ISO Abbreviation: Haemostasis Publication Date: 1977 |
Date Detail:
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Created Date: 1977-12-29 Completed Date: 1977-12-29 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0371574 Medline TA: Haemostasis Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 205-12 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Barium Cycloheximide Factor V / biosynthesis* Factor XI / biosynthesis* Factor XII / biosynthesis* Liver / metabolism* Rats |
| Chemical | |
Reg. No./Substance:
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66-81-9/Cycloheximide; 7440-39-3/Barium; 9001-24-5/Factor V; 9001-30-3/Factor XII; 9013-55-2/Factor XI |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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