| Generation of cloned transgenic pigs rich in omega-3 fatty acids. | |
| | |
MedLine Citation:
|
PMID: 16565727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Meat products are generally low in omega-3 (n-3) fatty acids, which are beneficial to human health. We describe the generation of cloned pigs that express a humanized Caenorhabditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase. The hfat-1 transgenic pigs produce high levels of n-3 fatty acids from n-6 analogs, and their tissues have a significantly reduced ratio of n-6/n-3 fatty acids (P < 0.001). |
| | |
Authors:
|
Liangxue Lai; Jing X Kang; Rongfeng Li; Jingdong Wang; William T Witt; Hwan Yul Yong; Yanhong Hao; David M Wax; Clifton N Murphy; August Rieke; Melissa Samuel; Michael L Linville; Scott W Korte; Rhobert W Evans; Thomas E Starzl; Randall S Prather; Yifan Dai |
Related Documents
:
|
19307467 - Plasma fatty acid composition as a predictor of arterial stiffness and mortality. 20868657 - Ethyl-eicosapentaenoate modulates changes in neurochemistry and brain lipids induced by... 2366627 - Phospholipase a activity of cultured rat ventricular myocyte is affected by the nature ... 9805217 - Intake of very-long-chain n-3 fatty acids related to social status and lifestyle. 9688677 - Inhibition of renal arachidonic acid omega-hydroxylase activity with abt reduces blood ... 19343517 - Changes in free amino acid profile of red snapper lutjanus campechanus, eggs, and devel... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-03-26 |
Journal Detail:
|
Title: Nature biotechnology Volume: 24 ISSN: 1087-0156 ISO Abbreviation: Nat. Biotechnol. Publication Date: 2006 Apr |
Date Detail:
|
Created Date: 2006-04-07 Completed Date: 2006-06-29 Revised Date: 2011-10-12 |
Medline Journal Info:
|
Nlm Unique ID: 9604648 Medline TA: Nat Biotechnol Country: United States |
Other Details:
|
Languages: eng Pagination: 435-6 Citation Subset: IM |
Affiliation:
|
Division of Animal Science, University of Missouri-Columbia, Columbia, Missouri 65211, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Animals, Genetically Modified / metabolism* Caenorhabditis elegans Cloning, Organism / methods* Fatty Acids, Omega-3 / genetics*, metabolism* Humans Meat / analysis Muscle, Skeletal / metabolism Protein Engineering / methods* Swine / physiology* Tissue Distribution |
| Grant Support | |
ID/Acronym/Agency:
|
CA79553/CA/NCI NIH HHS; P30 DK040561-11/DK/NIDDK NIH HHS; R01 DK064207-01/DK/NIDDK NIH HHS; R01 RR013438/RR/NCRR NIH HHS; R01DK64207/DK/NIDDK NIH HHS; U42 RR018877/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids, Omega-3 |
| Comments/Corrections | |
Comment In:
|
Nat Biotechnol. 2006 Dec;24(12):1472-3
[PMID:
17160035
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ca(2+)-synaptotagmin directly regulates t-SNARE function during reconstituted membrane fusion.
Next Document: Transdermal protein delivery by a coadministered peptide identified via phage display.