Document Detail

Generation of chromosome size polymorphism during in vivo mitotic multiplication of Plasmodium berghei involves both loss and addition of subtelomeric repeat sequences.
MedLine Citation:
PMID:  1974695     Owner:  NLM     Status:  MEDLINE    
Extensive chromosome size polymorphism arises in Plasmodium berghei during in vivo mitotic multiplication. Size differences between homologous chromosomes involve rearrangements occurring in the subtelomeric portions while internal chromosomal regions do not contribute significantly to chromosome size polymorphism. Differences in the copy number of a 2.3-kb subtelomeric repeated unit are shown to correlate with size variations, and in at least one case to account completely for the size difference between two variants of the same chromosome.
M Ponzi; C J Janse; E Dore; R Scotti; T Pace; T J Reterink; F M van der Berg; B Mons
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and biochemical parasitology     Volume:  41     ISSN:  0166-6851     ISO Abbreviation:  Mol. Biochem. Parasitol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-09-17     Completed Date:  1990-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006324     Medline TA:  Mol Biochem Parasitol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  73-82     Citation Subset:  IM    
Laboratorio di Biologia Cellulare, Istituto Superiore di Sanità, Rome, Italy.
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MeSH Terms
Blotting, Southern
Flow Cytometry
Nucleic Acid Hybridization
Plasmodium berghei / cytology,  genetics*
Polymorphism, Restriction Fragment Length*
Repetitive Sequences, Nucleic Acid*

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