Document Detail

Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors.
MedLine Citation:
PMID:  23299414     Owner:  NLM     Status:  MEDLINE    
In the adult thymus, the development of self-tolerant thymocytes requires interactions with thymic epithelial cells (TECs). Although both cortical and medullary TECs (cTECs/mTECs) are known to arise from common bipotent TEC progenitors, the phenotype of these progenitors and the timing of the emergence of these distinct lineages remain unclear. Here, we have investigated the phenotype and developmental properties of bipotent TEC progenitors during cTEC/mTEC lineage development. We show that TEC progenitors can undergo a stepwise acquisition of first cTEC and then mTEC hallmarks, resulting in the emergence of a progenitor population simultaneously expressing the cTEC marker CD205 and the mTEC regulator Receptor Activator of NF-κB (RANK). In vivo analysis reveals the capacity of CD205(+) TECs to generate functionally competent cortical and medullary microenvironments containing both cTECs and Aire(+) mTECs. Thus, TEC development involves a stage in which bipotent progenitors can co-express hallmarks of the cTEC and mTEC lineages through sequential acquisition, arguing against a simple binary model in which both lineages diverge simultaneously from bipotent lineage negative TEC progenitors. Rather, our data reveal an unexpected overlap in the phenotypic properties of these bipotent TECs with their lineage-restricted counterparts.
Song Baik; Eric J Jenkinson; Peter J L Lane; Graham Anderson; William E Jenkinson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-02-11
Journal Detail:
Title:  European journal of immunology     Volume:  43     ISSN:  1521-4141     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-13     Completed Date:  2013-05-02     Revised Date:  2014-03-26    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  589-94     Citation Subset:  IM    
Copyright Information:
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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MeSH Terms
Antigens, CD / metabolism*
Cell Differentiation
Cell Lineage / immunology
Epithelial Cells / cytology*,  metabolism*
Lectins, C-Type / metabolism*
Receptor Activator of Nuclear Factor-kappa B / metabolism
Receptors, Cell Surface / metabolism*
Thymocytes / cytology*,  metabolism*
Thymus Gland / cytology*
Transcription Factors / metabolism*
Grant Support
080882//Wellcome Trust; G0401620//Medical Research Council; G1000213//Medical Research Council; G1001055//Medical Research Council; //Medical Research Council
Reg. No./Substance:
0/APECED protein; 0/Antigens, CD; 0/DEC-205 receptor; 0/Lectins, C-Type; 0/Receptor Activator of Nuclear Factor-kappa B; 0/Receptors, Cell Surface; 0/Transcription Factors
Comment In:
Eur J Immunol. 2013 Mar;43(3):580-3   [PMID:  23404610 ]

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