Document Detail


Generation of two- and three-dimensional lacrimal gland constructs.
MedLine Citation:
PMID:  20502026     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Aqueous tear deficiency due to lacrimal gland insufficiency is one of the major causes of dry eye. In severe cases, such as Sjoegren's syndrome, Stevens-Johnson syndrome or ocular cicatricial pemphigoid, therapy with artificial tears can be insufficient to relieve severe discomfort. Engineering a lacrimal gland construct may offer a suitable alternative transplant with a tear-like secretion. However, the reconstruction of a complex structure such as the lacrimal gland is challenging, and a lacrimal gland substitute must meet several criteria. It has to contain enough functional lacrimal gland cells to produce an adequate amount of tear fluid, and a suitable matrix is needed to deliver the cells to the patient. The growing field of regenerative medicine offers promising new prospects for lacrimal gland reconstruction. This article summarizes our group's current work in developing models for lacrimal gland reconstruction, and also discusses the perspectives of a tissue-engineered lacrimal gland for future applications.
Authors:
S Schrader; L Liu; K Kasper; G Geerling
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Publication Detail:
Type:  Journal Article     Date:  2010-05-18
Journal Detail:
Title:  Developments in ophthalmology     Volume:  45     ISSN:  0250-3751     ISO Abbreviation:  Dev Ophthalmol     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8010321     Medline TA:  Dev Ophthalmol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  49-56     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Affiliation:
Cells for Sight Transplantation and Research Programme, Ocular Biology and Therapeutics, UCL Institute of Ophthalmology, London, UK. mail@stefanschrader.de
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