Document Detail


Generation of Transgenic X. laevis Models of Retinal Degeneration.
MedLine Citation:
PMID:  23150364     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Transgenic models are invaluable tools for researching retinal degenerative disease mechanisms. However, they are time-consuming and expensive to generate and maintain. We have developed an alternative to transgenic rodent models of retinal degeneration using transgenic Xenopus laevis. We have optimized this system to allow rapid analysis of transgene effects in primary transgenic animals, thereby providing an alternative to establishing transgenic lines, and simultaneously allowing rigorous comparisons between the effects of different transgenes.
Authors:
Beatrice M Tam; Christine C-L Lai; Zusheng Zong; Orson L Moritz
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  935     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  113-125     Citation Subset:  -    
Affiliation:
Department of Ophthalmology & Visual Sciences, University of British Columbia, Vancouver, BC, Canada.
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