| Generation of Transgenic X. laevis Models of Retinal Degeneration. | |
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MedLine Citation:
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PMID: 23150364 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Transgenic models are invaluable tools for researching retinal degenerative disease mechanisms. However, they are time-consuming and expensive to generate and maintain. We have developed an alternative to transgenic rodent models of retinal degeneration using transgenic Xenopus laevis. We have optimized this system to allow rapid analysis of transgene effects in primary transgenic animals, thereby providing an alternative to establishing transgenic lines, and simultaneously allowing rigorous comparisons between the effects of different transgenes. |
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Authors:
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Beatrice M Tam; Christine C-L Lai; Zusheng Zong; Orson L Moritz |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Methods in molecular biology (Clifton, N.J.) Volume: 935 ISSN: 1940-6029 ISO Abbreviation: Methods Mol. Biol. Publication Date: 2013 |
Date Detail:
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Created Date: 2012-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9214969 Medline TA: Methods Mol Biol Country: - |
Other Details:
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Languages: ENG Pagination: 113-125 Citation Subset: - |
Affiliation:
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Department of Ophthalmology & Visual Sciences, University of British Columbia, Vancouver, BC, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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