Document Detail


Generation of the NUP98-TOP1 fusion transcript by the t(11;20) (p15;q11) in a case of acute monocytic leukemia.
MedLine Citation:
PMID:  12645654     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A rare chromosomal translocation, (11;20)(p15;q11), was detected in a 29-year-old male patient diagnosed with acute monocytic leukemia (AMoL) according to the French-American-British classification criteria. Whole chromosome painting analysis with paints for chromosomes 11 and 20 confirmed the result of conventional cytogenetic analysis. Reverse transcriptase polymerase chain reaction revealed the NUP98-TOP1 fusion transcript. To our knowledge, this is the second report of the translocation involving NUP98 and TOP1 genes in AMoL. On reviewing the literature, we suggest that t(11;20)(p15q11) is associated with myelocytic disorders rather than lymphocytic proliferative diseases.
Authors:
Suning Chen; Yongquan Xue; Zhong Chen; Yu Guo; Yafang Wu; Jinlan Pan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  140     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-03-20     Completed Date:  2003-04-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  153-6     Citation Subset:  IM    
Affiliation:
Leukemia Research Unit, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amino Acid Sequence
Chromosome Painting
Chromosomes, Human, Pair 11 / genetics*,  ultrastructure
Chromosomes, Human, Pair 20 / genetics*,  ultrastructure
DNA Topoisomerases, Type I / genetics*
Fatal Outcome
Humans
Leukemia, Monocytic, Acute / genetics*,  pathology
Lymphocytes / pathology
Male
Molecular Sequence Data
Myeloid Cells / pathology
Neoplasm Proteins / genetics*
Nuclear Pore Complex Proteins / genetics*
Oncogene Proteins, Fusion / genetics*
Reverse Transcriptase Polymerase Chain Reaction
Translocation, Genetic / genetics*
Chemical
Reg. No./Substance:
0/NUP98-TOP1 fusion protein, human; 0/Neoplasm Proteins; 0/Nuclear Pore Complex Proteins; 0/Nup98 protein, human; 0/Oncogene Proteins, Fusion; EC 5.99.1.2/DNA Topoisomerases, Type I

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