| Generation of Melanocytes from Neural Crest Cells. | |
| | |
MedLine Citation:
|
PMID: 21310010 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The neural crest is a transient structure in vertebrate embryos that generates multiple neural and mesenchymal cell types as well as melanocytes. Melanocytes in the skin either derive directly from neural crest cells populating the skin via a dorsolateral migratory pathway or arise by detaching from nerves innervating the skin. Several transcription factors, such as FoxD3, Sox10, Pax3, and Mitf, take part in a genetic network regulating melanocyte formation from the neural crest. The activity of these intrinsic factors is controlled and modulated by extracellular signals including canonical Wnt, Edn, Kitl, and other signals that remain to be identified. Here we summarize the current view of how melanocytes are specified from the neural crest and put this process into the context of spatiotemporal lineage decisions in neural crest cells. |
| | |
Authors:
|
Lukas Sommer |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-10 |
Journal Detail:
|
Title: Pigment cell & melanoma research Volume: - ISSN: 1755-148X ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-2-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101318927 Medline TA: Pigment Cell Melanoma Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 John Wiley & Sons A/S. |
Affiliation:
|
Cell and Developmental Biology, Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genetic tool development underpins recent advances in thermophilic whole-cell biocatalysts.
Next Document: Performance of three biometry devices in patients with different grades of age-related cataract.