Document Detail


Generalized vitiligo after lymphocyte infusion for relapsed leukaemia.
MedLine Citation:
PMID:  11899125     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vitiligo is an autoimmune disease caused by T-lymphocyte-mediated destruction of melanocytes. We describe two patients with generalized vitiligo caused iatrogenically after donor lymphocyte infusion (DLI) for leukaemia relapse over 3 years after bone marrow transplantation (BMT). Neither the sibling donor nor the recipient had vitiligo or other autoimmune diseases, and vitiligo did not occur after the first BMT. DLI was accompanied by skin graft-versus-host disease in both cases, which was controlled with immunosuppression. However, over several months, progressive generalized and persistent skin depigmentation occurred in both patients. Peripheral blood molecular studies showed the complete disappearance of host haematolymphopoiesis. The specific destruction of melanocytes in both patients was therefore probably mediated by new alloreactive lymphocytes infused from the donors.
Authors:
W Y Au; C K Yeung; H H Chan; A K Lie
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  145     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-03-18     Completed Date:  2002-03-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1015-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, Queen Mary Hospital, University of Hong Kong. auwing@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Autoimmune Diseases / etiology*
Bone Marrow Transplantation
Female
Follow-Up Studies
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy*
Lymphocyte Transfusion / adverse effects*
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy*
Recurrence
Vitiligo / etiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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