Document Detail

Generalized non-Langerhans cell histiocytosis: four cases illustrate a spectrum of disease.
MedLine Citation:
PMID:  7737766     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The proliferation of non-Langerhans cell histiocytes is a poorly understood process of unknown cause. Variation in the clinical features and/or histopathology of histiocytic proliferation has led to subclassification of the general category of non-Langerhans cell histiocytes. Although the current classification may provide some useful generalizations in regard to the anticipated clinical course, wide variability in presentation and outcome make this classification less than optimal when dealing with individual patients. The objectives of the study were to present four cases of generalized non-Langerhans cell histiocytosis. MATERIALS AND METHODS: Medical records and slides of four patients diagnosed with non-Langerhans cell histiocytosis at the Cleveland Clinic are reviewed. RESULTS: The patients exhibit features of more than one subtype of non-Langerhans cell histiocytosis. CONCLUSION: The overlap among the clinical and histologic features of the generalized cutaneous non-Langerhans cell histiocytic disorders suggests that they represent one disease entity with a wide spectrum of presentations rather than many distinct disorders.
E A Mullans; T N Helm; J S Taylor; K F Helm; J W Olin; W F Bergfeld
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  International journal of dermatology     Volume:  34     ISSN:  0011-9059     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-06-06     Completed Date:  1995-06-06     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  106-12     Citation Subset:  IM    
Department of Internal Medicine of Baylor University, College of Medicine, Houston, Texas, USA.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Chlorambucil / therapeutic use
Fatal Outcome
Histiocytosis, Non-Langerhans-Cell* / diagnosis,  pathology,  physiopathology,  therapy
Middle Aged
Prednisone / therapeutic use
Remission, Spontaneous
Skin / pathology
Reg. No./Substance:
305-03-3/Chlorambucil; 53-03-2/Prednisone

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