| Generalized lymphadenopathy and nephrotic syndrome as a manifestation of mephenytoin (mesantoin) toxicity. | |
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MedLine Citation:
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PMID: 1246508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This report describes a patient who developed marked generalized adenopathy and nephrotic syndrome while receiving mephenytoin (mesantoin) for a seizure disorder. Renal biopsy showed a diffuse proliferative glomerulonephritis. Lymph node histopathology revealed replacement of parenchyma with lymphocytes, eosinophils, and reticuloendothelial cells. A hypersensitivity reaction is postulated as the etiology of both these processes. |
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Authors:
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C Snead; N Siegel; J Hayslett |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatrics Volume: 57 ISSN: 0031-4005 ISO Abbreviation: Pediatrics Publication Date: 1976 Jan |
Date Detail:
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Created Date: 1976-03-15 Completed Date: 1976-03-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 98-101 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Edema / chemically induced Epilepsy / drug therapy Humans Hydantoins / adverse effects* Lymphatic Diseases / chemically induced* Male Mephenytoin / adverse effects*, therapeutic use Nephrotic Syndrome / chemically induced* |
| Chemical | |
Reg. No./Substance:
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0/Hydantoins; 50-12-4/Mephenytoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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