| Generalized lymphadenopathy and T cell abnormalities in hemophilia A. | |
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MedLine Citation:
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PMID: 6223133 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two patients with hemophilia A had generalized lymphadenopathy, lymphopenia, elevated IgG values, depressed T4 (helper) lymphocytes, elevated T8 (suppressor) lymphocytes, and abnormally low T4/T8 ratios. One of the patients, who also had hepatosplenomegaly, underwent cervical lymph node biopsy; the node contained 43% T8-lymphocytes, a marked elevation over the small fraction of T8 cells usually found in lymph nodes. These patients may have a form of the acquired immune deficiency syndrome described in male homosexuals, Haitians, intravenous drug abusers, and recently, in patients with hemophilia. We studied T cell phenotypes in 43 patients with hemophilia. Fourteen of 28 patients given commercial factor VIII concentrates had abnormal T4/T8 ratios; none of nine patients who used cryoprecipitate had abnormal values. T4 helper cells were significantly lower, T8 suppressor cells significantly elevated, and T4/T8 ratios significantly lower in the lyophilized concentrate users and in patients with hemophilia as a total group. The type of therapeutic factor VIII replacement may alter the risk of developing T4/T8 abnormalities or AIDS. |
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Authors:
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J C Gill; J E Menitove; D Wheeler; R H Aster; R R Montgomery |
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Publication Detail:
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Type: Case Reports; Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of pediatrics Volume: 103 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1983 Jul |
Date Detail:
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Created Date: 1983-08-17 Completed Date: 1983-08-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 18-22 Citation Subset: AIM; IM; X |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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transmission Child Factor VIII / adverse effects Fibrinogen / adverse effects Hemophilia A / complications, immunology*, therapy Humans Leukocyte Count Lymphatic Diseases / etiology* Male T-Lymphocytes, Helper-Inducer / analysis* T-Lymphocytes, Regulatory / analysis* |
| Chemical | |
Reg. No./Substance:
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0/cryoprecipitate coagulum; 9001-27-8/Factor VIII; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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