Document Detail

Generalized eruptive histiocytoma evolving into xanthoma disseminatum in a 4-year-old boy.
MedLine Citation:
PMID:  7662578     Owner:  NLM     Status:  MEDLINE    
We report a 4-year-old boy who developed a generalized and symmetrical eruption of brownish papules over a period of 8 months, with spontaneous regression of some lesions. Clinical, histopathological and ultrastructural studies were suggestive of the diagnosis of generalized eruptive histiocytoma (GEH). The clinical features subsequently changed to a generalized eruption of confluent, yellowish papules, and diabetes insipidus developed. The clinical, histopathological and ultrastructural features of the new lesions were those of xanthoma disseminatum with cerebral involvement. This evolution suggests that GEH and xanthoma disseminatum may be variants of a continuous spectrum of histiocytic diseases.
T Repiso; M Roca-Miralles; J Kanitakis; A Castells-Rodellas
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  132     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-10-10     Completed Date:  1995-10-10     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  978-82     Citation Subset:  IM    
Department of Dermatology, Hospital General Universitario Vall d'Hebron, Barcelona, Spain.
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MeSH Terms
Child, Preschool
Diabetes Insipidus / pathology*
Disease Progression
Histiocytoma, Benign Fibrous / pathology*
Histiocytosis, Non-Langerhans-Cell / pathology*
Skin Neoplasms / pathology*

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