| Generalized absence seizures with 10-15 Hz fast discharges. | |
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MedLine Citation:
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PMID: 10402089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To report clinical and EEG features in 5 adults with unusual, fast rhythmic discharges accompanying absence seizures. DESIGN AND METHODS: The 5 patients presented with uncontrolled seizures. All had EEG-video monitoring with recorded seizures. Video seizures were reviewed and ictal as well as interictal epileptiform activity was analyzed. The patients were followed up after appropriate therapy for a minimum of 6 months. RESULTS: There were 3 women and two men, with a mean age of 37 years (range: 23-59). Two patients had onset of absence seizures in childhood, one in adolescence and two after age 20. All patients also had generalized tonic-clonic seizures. Ictal EEG recordings showed generalized spike and wave (SW) discharges of variable dominant frequencies (2.5-6 Hz) and intermingled 10-15 Hz generalized rhythmic discharges which also occurred in isolation or as the dominant activity. Interictal recordings showed similar but shorter 2.5-6 Hz generalized SW discharges. The background activity was normal in 3 patients and mildly slow in two who had very frequent absence seizures during the recording period. Four patients became seizure free and one had 75% improvement on appropriate antiabsence therapy. CONCLUSIONS: The fast 10-15 Hz rhythmic discharges that we report appear to occur mostly in adult patients with absence, as well as, generalized tonic-clonic seizures. They can occur in isolation or be embedded in more typical SW discharges accompanying typical absence seizures. Their presence does not imply a poor prognosis for seizure control. |
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Authors:
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T Fakhoury; B Abou-Khalil |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Volume: 110 ISSN: 1388-2457 ISO Abbreviation: Clin Neurophysiol Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-08-02 Completed Date: 1999-08-02 Revised Date: 2008-09-10 |
Medline Journal Info:
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Nlm Unique ID: 100883319 Medline TA: Clin Neurophysiol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 1029-35 Citation Subset: IM |
Affiliation:
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Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA. Toufic.Fakhoury@mcmail.vanderbilt.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / physiopathology* Electroencephalography Epilepsy / physiopathology* Female Humans Male Middle Aged Prognosis |
| Comments/Corrections | |
Comment In:
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Clin Neurophysiol. 2001 Feb;112(2):404
[PMID:
11243238
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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