Document Detail

Generalized absence seizures with 10-15 Hz fast discharges.
MedLine Citation:
PMID:  10402089     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report clinical and EEG features in 5 adults with unusual, fast rhythmic discharges accompanying absence seizures. DESIGN AND METHODS: The 5 patients presented with uncontrolled seizures. All had EEG-video monitoring with recorded seizures. Video seizures were reviewed and ictal as well as interictal epileptiform activity was analyzed. The patients were followed up after appropriate therapy for a minimum of 6 months. RESULTS: There were 3 women and two men, with a mean age of 37 years (range: 23-59). Two patients had onset of absence seizures in childhood, one in adolescence and two after age 20. All patients also had generalized tonic-clonic seizures. Ictal EEG recordings showed generalized spike and wave (SW) discharges of variable dominant frequencies (2.5-6 Hz) and intermingled 10-15 Hz generalized rhythmic discharges which also occurred in isolation or as the dominant activity. Interictal recordings showed similar but shorter 2.5-6 Hz generalized SW discharges. The background activity was normal in 3 patients and mildly slow in two who had very frequent absence seizures during the recording period. Four patients became seizure free and one had 75% improvement on appropriate antiabsence therapy. CONCLUSIONS: The fast 10-15 Hz rhythmic discharges that we report appear to occur mostly in adult patients with absence, as well as, generalized tonic-clonic seizures. They can occur in isolation or be embedded in more typical SW discharges accompanying typical absence seizures. Their presence does not imply a poor prognosis for seizure control.
T Fakhoury; B Abou-Khalil
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  110     ISSN:  1388-2457     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-08-02     Completed Date:  1999-08-02     Revised Date:  2008-09-10    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  1029-35     Citation Subset:  IM    
Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
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MeSH Terms
Brain / physiopathology*
Epilepsy / physiopathology*
Middle Aged
Comment In:
Clin Neurophysiol. 2001 Feb;112(2):404   [PMID:  11243238 ]

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