Document Detail

Generalized Multinucleate Cell Angiohistiocytoma.
MedLine Citation:
PMID:  25492306     Owner:  NLM     Status:  Publisher    
Background:There are less than 100 cases of multinucleate cell angiohistiocytoma (MCA) currently reported in the literature. It occurs as a localized, asymptomatic, benign proliferation of the skin, characterized histologically by irregular multinucleate cells. Due to its novelty, the etiology of the disease and treatment options are still under investigation.Objective:To report a case of confirmed, generalized MCA along with a review of the literature on the histology, immunology, potential etiology, and treatment of MCA.Observations:The patient was a 41-year-old female with asymptomatic violaceous plaques found on the extensor arms, legs, and trunk. Histopathology revealed increased dilated vascularity and cellularity (composed of mononuclear histiocytes and a few angulated multinucleated giant cells) in the dermis.Conclusions:Overall, MCA is a poorly understood, distinct dermatologic phenomenon. Here we present a case of generalized MCA to further the understanding of this disease presentation.
Jennifer A E Doane; Kerri Purdy; Sylvia Pasternak
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Publication Detail:
Journal Detail:
Title:  Journal of cutaneous medicine and surgery     Volume:  18     ISSN:  1203-4754     ISO Abbreviation:  J Cutan Med Surg     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-10     Completed Date:  -     Revised Date:  2014-12-11    
Medline Journal Info:
Nlm Unique ID:  9614685     Medline TA:  J Cutan Med Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-3     Citation Subset:  -    
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