Document Detail


Generalized mechanical nerve pain hypersensitivity in children with episodic tension-type headache.
MedLine Citation:
PMID:  20530075     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The objective of this study was to analyze the presence of generalized pressure pain hypersensitivity over nerve tissues in trigeminal and nontrigeminal regions in children with frequent episodic tension-type headache (FETTH). METHODS: Thirty children, 7 boys and 23 girls (mean age: 8.8 +/- 1.7 years) with FETTH and 50 age- and gender-matched healthy children (14 boys, 36 girls; mean age: 8.5 +/- 2.1 years; P = .743) were recruited. Pressure pain thresholds (PPTs) were bilaterally assessed over supra-orbital (V1), infra-orbital (V2), mental (V3), median (C5), radial (C6), and ulnar (C7) nerves by an assessor who was blinded to the patient's condition. RESULTS: The analysis of variance showed that PPT levels were significantly bilaterally decreased over both trigeminal (supra-orbital, infra-orbital, and mental) and nontrigeminal (median, ulnar, and radial) nerves in children with FETTH as compared with control subjects (all sites, P < .001). There was a greater magnitude of PPT decrease within trigeminal nerves as compared with nontrigeminal nerves (P < .03). PPTs over infra-orbital (r(s) = -0.4, P < .05) and radial (r(s) = -0.5, P < .01) nerves were negatively correlated with the duration of headache attacks (P < .05). CONCLUSIONS: Our study revealed bilateral and generalized pressure hypersensitivity over both trigeminal and nontrigeminal nerves in children with FETTH. Diffuse hypersensitivity of peripheral nerves evidences the presence of hyperexcitability of the central nervous system in children with FETTH.
Authors:
Daniel M Fernández-Mayoralas; César Fernández-de-las-Peñas; Ricardo Ortega-Santiago; Silvia Ambite-Quesada; Rodrigo Jiménez-García; Alberto Fernández-Jaén
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-07
Journal Detail:
Title:  Pediatrics     Volume:  126     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-02     Completed Date:  2010-07-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e187-94     Citation Subset:  AIM; IM    
Affiliation:
Department of Neuropediatry, Hospital Quirón de Madrid, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Case-Control Studies
Child
Confidence Intervals
Female
Humans
Male
Neuralgia / diagnosis*
Pain Measurement
Pain Threshold / physiology*
Physical Stimulation / methods
Pressure
Probability
Prognosis
Recurrence
Reference Values
Tension-Type Headache / physiopathology*
Trigeminal Nerve / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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